28495-01-4Relevant academic research and scientific papers
Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles
Kumar, Ajay,Lohan, Poonam,Aneja, Deepak K.,Gupta, Girish Kumar,Kaushik, Dhirender,Prakash, Om
experimental part, p. 81 - 89 (2012/07/14)
Two series of compounds namely, 4-aryl/heteroaryl hydrazino-3-acetyl-6- methyl-2H-pyran-2-ones (4a-4j) and pyrano[4,3-c]pyrazoles (6a-6e and 6g) were synthesized starting from 3-acetyl-4-chloro-6-methyl-2H-pyran-2-one (2). Estimation of pharmacotherapeuti
Synthesis of Pyranopyrazol-4(1H)-ones and -4(2H)-ones from Dehydroacetic Acid. Homo- and Heteronuclear Selective NOE Measurements for Unambiguous Structure Assignment
Cantos, Albert,March, Pedro de,Moreno-Manas, Marcial,Pla, Anna,Sanchez-Ferrando, Francisco,Virgili, Albert
, p. 4425 - 4432 (2007/10/02)
Cyclization of dehydroacetic acid N-substituted hydrazones furnished 1-substituted 3,6-dimethylpyranopyrazol-4(1H)-ones, together with varying amounts of N,N'-disubstituted 5-hydroxy-3-methyl-4-(3-methyl-1H-pyrazol-5-yl)-1H-pyrazoles.The same pyranopyrazolones were obtained regioselectively without side reactions from N-alkylhydrazines and 4-chloro-3-(1-chlorovinyl)-6-methyl-2H-pyran-2-one, ("Dehydroacetchlorid"), while N-arylhydrazines gave the 2-aryl-3,6-dimethylpyranopyrazol-4(2H)-ones.NMR NOE methods, including long-range selective heteronuclear 13C NOE enhancement measurements, allowed unambiguous between -4(1H)-ones and -4(2H)-ones.
SYNTHESIS AND UNAMBIGUOUS ASSIGNMENT OF STRUCTURE TO PYRANOPYRAZOL-4(1H)-ONES AND -4(2H)-ONES
Cantos, Albert,March, Pere De,Moreno-Manas, Marcial,Pla, Anna,Sanchez-Ferrando, Francisco,Virgili, Albert
, p. 295 - 298 (2007/10/02)
A clean synthesis of pyranopyrazolones is described.The reactions of 4-chloro-3-(1-chlorovinyl)-6-methyl-2-pyrone with arylhydrazines give pyranopyrazol-4(2H)-ones as the only identified products.However, the isomeric pyranopyrazol-4(1H)-one
