2851-08-3

Basic information

• Product Name: 2-piperidinobenzothiazole
• Synonyms: 2-piperidinobenzothiazole;Benzothiazole, 2-(1-piperidinyl)- (9CI);2-(Piperidin-1-yl)benzothiazole;2-(1-Piperidinyl)-1,3-benzothiazole;2-(1-Piperidinyl)benzothiazole;NSC55897;2-(Piperidin-1-yl)benzo[d]thiazole
• CAS NO: 2851-08-3
• Molecular Formula: C₁₂H₁₄N₂S
• Molecular Weight: 218.31796
• EINECS: 220-658-4
• Product Categories: BENZOTHIAZOLE
• Mol File: 2851-08-3.mol
• Article Data: 38

Chemical Properties

• Melting Point: 95-96℃
• Boiling Point: 349.5°Cat760mmHg
• Flash Point: 165.2°C
• Appearance: /
• Density: 1.222
• Vapor Pressure: 4.67E-05mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 2-piperidinobenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-piperidinobenzothiazole(2851-08-3)
• EPA Substance Registry System: 2-piperidinobenzothiazole(2851-08-3)

Safety Data

• Hazardous Substances Data: 2851-08-3(Hazardous Substances Data)

Usage

General Description

2-piperidinobenzothiazole is a chemical compound with the molecular formula C13H13N3S. It is commonly used in the rubber industry as an accelerator in the vulcanization process, where it helps to speed up the curing of rubber products by promoting cross-linking between polymer chains. It is also utilized in the production of pharmaceuticals and agrochemicals. However, it is important to handle 2-piperidinobenzothiazole with caution, as it is classified as a hazardous substance and can cause skin and eye irritation, as well as respiratory problems if inhaled. Additionally, it has been identified as a potential environmental hazard and is subject to strict regulations regarding its use and disposal.

InChI:InChI=1/C12H14N2S/c1-4-8-14(9-5-1)12-13-10-6-2-3-7-11(10)15-12/h2-3,6-7H,1,4-5,8-9H2

Upstream product

• 110-89-4 piperidine 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 941-57-1 benzothiazole-2-sulphonic acid 
• 626-67-5 N-methylcyclohexylamine 
• 22801-60-1 3-(piperidin-1-yl)-1,2-benzoisothiazole 
• 2591-86-8 N-Formylpiperidine 
• 95-16-9 1,3-Benzothiazole 
• 175694-99-2 (2-isocyanophenyl)(methyl)sulfane 
• 1493-27-2 ortho-nitrofluorobenzene 
• 3058-47-7 methyl 2-nitrophenyl sulfide 
• 2987-53-3 2-(Methylthio)aniline 
• 18550-49-7 N-formyl-o-thioanisidine 
• 26773-65-9 N-piperidin-2-benzothiazole sulfenamide 
• 120-78-5 di(benzothiazol-2-yl)disulfide 

Relevant articles and documents

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Palladium catalyzed amination of 2-chloro-1,3-azole derivatives: Mild entry to potent H1- antihistaminic norastemizole

Palladium-catalyzed selective amination of 4-fluorobenzyl-2-chlorobenzimidazole with 4-aminopiperidine provided a simple solution for the norastemizole synthesis. Pd-catalyzed amination of other 2-chloro-1,3-Azole derivatives are exploited.

Copper(ii) ions supported on functionalized graphene oxide: an organometallic nanocatalyst for oxidative amination of azolesviaC-H/C-N bond activation

Graphene oxide (GO) was chemically modified withpara-aminobenzoic acid (PABA) to immobilize copper(ii) ions on its surface and used as a nanocatalyst for the oxidative C(sp2)-H bond amination reaction. A practical method to prepare Cu2+supported onpara-aminobenzoic acid grafted on GO was reported. The prepared Cu2+@GO/PABA was characterized by FT-IR, XRD, SEM, AFM, TEM, UV-Vis, and ICP techniques. The results showed that the morphology, distribution, and loading of copper ions could be well-adjusted by grafting of PABA on GO. Moreover, just 2 mol% of Cu2+@GO-PABA could catalyze the C-H activation reaction of benzoxazole and benzothiazole with secondary amines in >94% yields. Also, the catalyst showed very good recyclability and much less leaching of the Cu into the reaction solution. The high activity of Cu2+@GO-PABA can be ascribed to the good synergistic effects of Cu2+andpara-aminobenzoic acid grafted on graphene oxide.

N-Iodosuccinimide mediated intramolecular oxidative C(sp 2)-S bond formation for the synthesis of 2-aminobenzothiazole derivatives

An extremely efficient synthetic method for the preparation of 2-aminobenzothiazole derivatives starting from arylthioureas by using N-iodosuccinimide has been reported. This protocol features a mild reaction conditions, a short reaction time, and metal-free oxidative conditions for C (sp 2)-S bond construction.