3058-47-7

Basic information

• Product Name: 2-NITROTHIOANISOLE
• Synonyms: 1-Methylsulfanyl-2-nitro-benzene;Benzene,1-(methylthio)-2-nitro-;methyl-(2-nitro-phenyl)-sulfide;2-NITROTHIOANISOLE;o-(Methylthio)nitrobenzene;o-Nitrothioanisole;1-(Methylthio)-2-nitrobenzene;1-Methylthio-2-nitrobenzene
• CAS NO: 3058-47-7
• Molecular Formula: C₇H₇NO₂S
• Molecular Weight: 169.2
• Product Categories: Anisole
• Mol File: 3058-47-7.mol
• Article Data: 24

Chemical Properties

• Melting Point: 64.5°C
• Boiling Point: 264.7 °C at 760 mmHg
• Flash Point: 113.9 °C
• Appearance: /
• Density: 1.2628
• Vapor Pressure: 0.0156mmHg at 25°C
• Refractive Index: 1.6246 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive: Stench
• CAS DataBase Reference: 2-NITROTHIOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITROTHIOANISOLE(3058-47-7)
• EPA Substance Registry System: 2-NITROTHIOANISOLE(3058-47-7)

Safety Data

• Hazardous Substances Data: 3058-47-7(Hazardous Substances Data)

Usage

General Description

2-Nitrothioanisole is a chemical compound with the molecular formula C7H7NO3S. It is an aromatic nitro compound that contains a nitro group (-NO2) and a thioether group (-S-) attached to a methoxy group (-OCH3). 2-Nitrothioanisole is a clear, yellow liquid with a faint odor, and it is commonly used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis and as a precursor for the preparation of other compounds, such as dyes and pharmaceutical ingredients. The chemical properties of 2-Nitrothioanisole make it a versatile building block for various chemical reactions and applications in the manufacturing industry.

InChI:InChI=1/C7H7NO2S/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3

Upstream product

• 624-92-0 Dimethyldisulphide 
• 88-73-3 2-Chloronitrobenzene 
• 577-19-5 2-nitrophenyl bromide 
• 168618-42-6 (2-methylsulfanylphenyl)boronic acid 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 110-05-4 di-tert-butyl peroxide 
• 15163-59-4 potassium o-nitrobenzoate 
• 67-68-5 dimethyl sulfoxide 
• 552-16-9 ortho-nitrobenzoic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 3908-55-2 Trimethyl(methylthio)silane 
• 528-29-0 1,2-Dinitrobenzene 
• 5188-07-8 sodium thiomethoxide 
• 75355-13-4 2-nitrophenyl sulphide anion 

Downstream Products

• 856356-44-0 bis-(2-methylsulfanyl-phenyl)-diazene-N-oxide 
• 107682-72-4 bis-(2-methylsulfanyl-phenyl)-diazene 
• 132016-28-5 methyl-(2-nitro-phenyl)-sulfoxide 
• 2976-34-3 1-(methylsulfonyl)-2-nitrobenzene 
• 345635-46-3 4-bromo-1-methylsulfanyl-2-nitro-benzene 
• 2987-53-3 2-(Methylthio)aniline 
• 857770-01-5 N,N'-bis-(2-methylsulfanyl-phenyl)-hydrazine 
• 13118-30-4 dimethyl-(2-nitro-phenyl)-sulfonium ; methyl sulfate 
• 224635-35-2 3-methylthio-4-[3-(2-methylphenyl)ureido]phenylacetic acid 
• 6278-86-0 N₂-(4-bromophenyl)-1,3-benzothiazol-2-amine 
• 1843-21-6 N-phenyl-2-benzothiazolamine 
• 24622-31-9 N-butylbenzo[d]thiazol-2-amine 
• 24255-48-9 N,N-diethylbenzo[d]thiazol-2-amine 
• 19983-29-0 2-(pyrrolidin-1-yl)benzo[d]thiazole 

Relevant articles and documents

Stabilisation of Nitrophenyl Disulphide Ions in Dimethylacetamide

2-Nitrophenyl and 4-nitrophenyl disulphide ions are stabilised in aprotic dipolar solvents and solutions of these ions are obtained in dimethylacetamide by nucleophilic attack of sulphur by the corresponding thiolates.

Copper-Catalyzed Methylthiolation of Aryl Iodides and Bromides with Dimethyl Disulfide in Water

An efficient route to aryl methyl sulfides through the copper-catalyzed coupling reaction of aryl iodides or bromides with dimethyl disulfide in water is described. Electron-donating and electron-withdrawing functional groups in the substrates were tolerated, and the corresponding products were obtained in moderate to good yields.

Industrial production method of o-nitrobenzenesulfonyl chloride

The invention discloses an industrial production method of o-nitrobenzenesulfonyl chloride. The method comprises the following steps that o-nitrochlorobenzene and sodium methyl mercaptide are subjected to an etherification reaction, filtering is conducted, an obtained filter cake is subjected to recrystallization, and through centrifugation separation and drying, a dry product of o-nitrobenzene dimethyl sulfide is obtained; the dry product of o-nitrobenzene dimethyl sulfide is subjected to a chlorination reaction in batches to obtain a wet crude product, an appropriate amount of hydrochloric acid is added in a chlorination reaction system, the chlorination reaction is carried out in a hydrophilic organic acid solvent, and the mole ratio of the o-nitrobenzene dimethyl sulfide to water during the chlorination reaction is 1:(5-15); a finished product of o-nitrobenzenesulfonyl chloride is obtained through refining and drying. Through HPLC detection, the content of the o-nitrobenzenesulfonyl chloride synthesized by means of the method is 98-98.5%; the yield is 0.72-0.75, the acquisition rate is 0.97 or above, the turbidity (ppm) is 1.5-2, and the melting point is 66-67 DEG C. By adopting the hydrophilic organic acid solvent, the problems about large-scale production discharging, yield and quality are solved, and meanwhile the purposes of mixed application and post-treatment separation of large-scale production water-soluble solvents are achieved.