285119-72-4Relevant articles and documents
A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters
Watanabe, Eiichi,Chen, Yiding,May, Oliver,Ley, Steven V.
supporting information, p. 186 - 191 (2019/12/24)
A practically useful coupling reaction between aromatic halides and redox-active esters was realized by nickel catalysis through the use of a packed zinc bed column in continuous flow. Multiple reuse of the column showed a negligible decrease in efficiency, affording high space/time yields. A wide range of substrates, including a number of heteroaryl halides and polyfunctional materials were coupled in generally good yields. Longer-time and larger-scale experiments further demonstrates the robustness of the system.
An accessible bicyclic architecture for synthetic lectins
Howgego, Joshua D.,Butts, Craig P.,Crump, Matthew P.,Davis, Anthony P.
supporting information, p. 3110 - 3112 (2013/06/27)
Bicyclic carbohydrate receptors are easier to synthesise than tri- or tetra-cyclic relatives, and are better adapted to bind monosaccharide residues with bulky appendages. Disaccharides containing β-glucosyl units are preferred substrates.
THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS
-
Page/Page column 15, (2010/03/31)
The invention provides compounds of formula I [INSERT CHEMICAL STRUCTURE HERE] (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
