285135-68-4

Upstream product

• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Downstream Products

• 257876-24-7 5-methyl-pyridine-2-sulfonic acid [6-chloro-2-(2-cyano-pyridine-4-yl)-5-(2-methoxy-phenoxy)-pyrimidine-4-yl]-amide 
• 370105-65-0 4-tert-butyl-N-[6-chloro-2-(2-cyano-pyridin-4-yl)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide 
• 257876-25-8 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-2-(2-cyano-pyridine-4-yl)-5-(2-methoxy-phenoxy)-pyrimidine-4-yl]-amide 
• 659727-54-5 4-tert-butyl-N-{6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-benzenesulfonamide 
• 659727-32-9 4-[4-(4-tert-butyl-benzenesulfonylamino)-6-chloro-5-(2-methoxy-phenoxy)-pyrimidin-2-yl]-N-hydroxy-pyridine-2-carboxamidine 
• 370105-31-0 5-isopropyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide 
• 659727-45-4 4-tert-butyl-N-{6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-benzenesulfonamide 
• 257876-27-0 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-2-[2-(hydrazino-imino-methyl)-pyridine-4-yl]-5-(2-methoxy-phenoxy)-pyrimidine-4-yl]-amide 
• 257876-29-2 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-[2-(1H-tetrazole-5-yl)-pyridine-4-yl]-pyrimidine-4-yl]-amide 
• 370105-89-8 5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide 
• 370105-30-9 4-[4-chloro-6-(5-isopropyl-pyridine-2-sulfonylamino)-5-(2-methoxy-phenoxy)-pyrimidin-2-yl]-N-hydroxy-pyridine-2-carboxamidine 
• 370105-87-6 5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide 
• 370105-86-5 4-[4-chloro-5-(2-methoxy-phenoxy)-6-(5-methyl-pyridine-2-sulfonylamino)-pyrimidin-2-yl]-N-hydroxy-pyridine-2-carboxamidine 
• 257876-26-9 5-methyl-pyridine-2-sulfonic acid [6-chloro-2-[2-(hydrazino-imino-methyl)-pyridine-4-yl]-5-(2-methoxy-phenoxy)-pyrimidine-4-yl]-amide 

Relevant academic research and scientific papers

Heterocyclic sulfamides

The compounds of formula (I) wherein R1, R2and X have the significance as given in the description, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction.

Carbamoylation process

The present invention is concerned with a novel process for the carbamoylation of substituted pyridines, especially with a process for the preparation of compounds of formula I wherein R4 to R8 represent hydrogen, lower-alkoxy or halogen; or optionally sa