285139-32-4

Basic information

• Product Name: L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)
• CAS NO: 285139-32-4
• Molecular Formula: C27H33N5O6S
• Molecular Weight: 555.655
• Mol File: 285139-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)(285139-32-4)
• EPA Substance Registry System: L-Tyrosine, N-[5-[[(4-methylphenyl)sulfonyl]amino]-4-pyrimidinyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)(285139-32-4)

Safety Data

• Hazardous Substances Data: 285139-32-4(Hazardous Substances Data)

Upstream product

• 285139-36-8 N-(5-aminopyrimidin-4-yl)-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 284486-57-3 L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester 
• 285139-31-3 N-(2-chloro-5-nitropyrimidin-4-yl)-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester 

Downstream Products

• 285139-33-5 N-[5-(N-methyl-N-4-toluenesulfonylamino)pyrimidin-4-yl]-L-4-(N,N-dimethylcarbarnyloxy)phenylalanine tert-butyl ester 
• 285139-34-6 N-[5-(N-methyl-N-4-toluenesulfonylamino)pyrimidin-4-yl]-L-4-(N,N-dimethylcarbarnyloxy)phenylalanine 

Relevant articles and documents

Arylsulfonamide pyrimidines as VLA-4 antagonists

A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4- ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo anima