28530-47-4

Upstream product

• 99-89-8 4-Isopropylphenol 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 4132-52-9 4-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione 

Downstream Products

• 1429061-80-2 (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide 

Relevant academic research and scientific papers

H2S-BASED THERAPEUTIC AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention concerns the field of neurodegenerative diseases, and in particular relates to compounds, pharmaceutical compositions and their uses in the protection of neuronal cells from inflammation and from oxidative stress in the early stage o

DESMETHYLANETHOLE TRITHIONE DERIVATIVES FOR THE TREATMENT OF DISEASES LINKED TO MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PRODUCTION

The present invention relates to desmethylanethole trithione ( AOX ) and derivatives thereof, especially derivatives of formula (I), for the prevention and treatment of diseases whose initiation and/or evolution relates to the production and effects of re

Assessment of the substituent constants of the -3-thioxo-l,2-dithiol-4- and -5-yl groups through pKa values measurements of 4 and 5-(hydroxy- or amino-phenyl)-l,2-dithiole-3-thiones in water at 298

The UV-VIS spectrophotometric assessment of the electronic substituent constants of the 3-thioxo-l,2-dithiol-4-and -5-yl and 3-oxo-l,2-dithiol-4- and -5-yl groups through pKa measurements in water of 4 and 5-(hydroxy or amino-phenyl)-1,2-dithiole-3-thiones and corresponding dithiolones has been performed. Linear free-enthalpy relationships based on pKa values of phenols and anilinium ions indicated a strong withdrawing effect for the 3-thioxo-l,2-dithiol-5-yl group by both an inductive and a resonance effect [?p- = 0.76, ?m = 0.44 (anilinium ions relationship) and ?p- = 0.97, ?m = 0.45 (phenols relationship)]. The corresponding 3-oxo group was slightly less attractive than the 3-thioxo one [?p- = 0.64 (anilinium ions) and ?p- = 0.78 (phenols)]. The 3-thioxo-l,2-dithiol-4-yl group and also its oxo analogue had only a weak withdrawing effect by an inductive effect (?p ca. ?p- ca.0.2) indicating a lack of conjugation between the dithiole and phenyl nuclei in 4-phenyldithiolethiones. The original 1,2-dithiole-3-thiones and 1,2-dithiol-3-ones used in correlations are described.

N2S2 tetradentate ligands for soft cationic species: preparation of new ligands of potential interest in nuclear medicine

The synthesis of N2S2 tetradentate ligands of the bis-(enaminothioester) type was carried out starting from 3-(methylthio)-3H-1,2-dithiolylium iodides and diamines.The title compounds, which are potential ligands for soft cationic species, can be obtained from 1,3-diaminopropan-2-ol and subsequently modified into the dissymmetrical succinic acid ester of the ligand and N-hydroxysuccinimide.The appendage of such a linking group on the chelating structure should allow further grafting to monoclonal antibodies in view of potential applications in nuclear medicine. 3H-1,2-dithiole-3-thione / 1,3-diaminopropan-2-ol / bis-(enaminothioester) / N2S2 tetradentate ligand / N-hydroxysuccinimidyl ester