1429061-80-2Relevant academic research and scientific papers
The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39)
Le Trionnaire, Sophie,Perry, Alexis,Szczesny, Bartosz,Szabo, Csaba,Winyard, Paul G.,Whatmore, Jacqueline L.,Wood, Mark E.,Whiteman, Matthew
, p. 728 - 736 (2014)
Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction. There is intense interest in developing pharmacological agents to generate H2S. We have synthesised a novel H2S donor molecule coupled to a mitochondria-targeting moiety (triphenylphosphonium; TPP+) and compared the effectiveness of the compound against a standard non-TPP+ containing H2S donor (GYY4137) in the inhibition of oxidative stress-induced endothelial cell death. Our study suggests mitochondria-targeted H2S donors are useful pharmacological tools to study the mitochondrial physiology of H2S in health and disease.
HYDROGEN SULFIDE RELEASING COMPOUNDS AND THEIR USE
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Paragraph 0216; 0217; 0218, (2015/07/22)
The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy
HYDROGEN SULFIDE RELEASING COMPOUNDS AND THEIR USE
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Page/Page column 30, (2013/04/13)
The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy
