28538-67-2Relevant academic research and scientific papers
1-Methyl-4-aryl-urazole (MAUra) labels tyrosine in proximity to ruthenium photocatalysts
Sato, Shinichi,Hatano, Kensuke,Tsushima, Michihiko,Nakamura, Hiroyuki
supporting information, p. 5871 - 5874 (2018/06/14)
We designed and synthesised peptides conjugated with proline linkers and ruthenium photocatalysts. These peptides were used as substrates to evaluate the photocatalyst-proximity dependences of candidates for tyrosine labelling reagents. The 1-methyl-4-aryl-urazole (MAUra) structure was found to be a novel tyrosyl radical trapping agent to label tyrosine residues effectively under the conditions where the ruthenium photocatalyst and tyrosine were in close proximity. Using a ruthenium photocatalyst conjugated to a carbonic anhydrase ligand, the target protein in a complex protein mixture was labelled with remarkable target selectivity by azide- or desthiobiotin-conjugated MAUra derivatives.
Proton-Transfer Chemistry of Urazoles and Related Imides, Amides, and Diacyl Hydrazides
Bausch, M. J.,David, B.,Dobrowolski, P.,Guadalupe-Fasano, C.,Gostowski, R.,et al.
, p. 5643 - 5651 (2007/10/02)
Equilibrium acidity constants have been determined for 1,2,4-triazolidine-3,5-dione (urazole), several substituted urazoles, and other related acids, in both dimethyl sulfoxide (DMSO) and aqueous solution.In DMSO, urazole has a pKa of 13.1.In w
UMSETZUNG VON AMINO-AZIMINEN MIT BASEN
Fahr, Egon,Richter, Monika J.,Schmitt-Sody, Wolfgang,Elbert, Rainer
, p. 3269 - 3272 (2007/10/02)
Amino-azimines of type (1) react at room temperature with bases ( ammonia, aliphatic amines, hydrazine and methyl-hydrazine, aqueous/ethanolic sodium hydroxide ) by clevage of the system to the =N- (amine) and the N=N=N- moieties (azide).
Ene Reaction of Triazolinediones with Alkenes. 2. Kinetics and Substituent Effects
Ohashi, Shinichi,Butler, George B.
, p. 3472 - 3476 (2007/10/02)
The kinetic measurements for the reaction of 4-substituted-1,2,4-triazoline-3,5-diones (4-R-TD; R=Ph, Me, p-MeOC6H4, p-NO2C6H4) with alkenes have been undertaken.The reactivity of alkenes was found to be very sensitive to substituent effects.The effects of solvent and substituent on TD were small.In the reaction of TD with ene products, side reactions as well as second-step ene reactions were observed.The reactions of 1-alkyl-4-phenyl-1,2,4-triazolidine-3,5-diones were investigated, and the reaction products were isolated.
