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2854-21-9

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2854-21-9 Usage

General Description

N-indomethacycloglycine is a chemical compound derived from the non-steroidal anti-inflammatory drug indomethacin and glycine. It is known for its ability to inhibit the enzyme cyclooxygenase, which is responsible for the production of inflammatory prostaglandins. This action makes N-indomethacycloglycine useful in reducing inflammation and pain. Additionally, it has been studied for its potential role in neuroprotection and in the treatment of neurological disorders. Its unique structure and pharmacological properties make it a promising compound for further research in the field of drug development and therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 2854-21-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,5 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2854-21:
(6*2)+(5*8)+(4*5)+(3*4)+(2*2)+(1*1)=89
89 % 10 = 9
So 2854-21-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H19ClN2O5/c1-12-16(10-19(25)23-11-20(26)27)17-9-15(29-2)7-8-18(17)24(12)21(28)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,23,25)(H,26,27)

2854-21-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Indomethacin glycine amide

1.2 Other means of identification

Product number -
Other names N-{[1-(4-chlorbenzyoyl)-2-methyl-5-methoxy-indol-3-yl]-acetyl}glycin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2854-21-9 SDS

2854-21-9Downstream Products

2854-21-9Relevant articles and documents

Synthesis and characterisation of glucosamine-NSAID bioconjugates

Jones, Rachel A.,Thillier, Yann,Panda, Siva S.,Rivera Rosario, Nicole,Hall, C. Dennis,Katritzky, Alan R.

, p. 8325 - 8335 (2015/01/08)

Strategies to couple non-steroidal anti-inflammatory drugs (NSAIDs) to a glucosamine hydrochloride salt via an amino acid linker are investigated and a series of novel NSAID-glucosamine bioconjugates have been prepared. This journal is

Synthesis of COX-2 and FAAH inhibitors

-

, (2008/06/13)

Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

Low molecular weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates and drug-spacer derivatives and their catabolism in renal cortex homogenates and lysosomal lysates

Franssen,Koiter,Kuipers,Bruins,Moolenaar,De Zeeuw,Kruizinga,Kellogg,Meijer

, p. 1246 - 1259 (2007/10/02)

Low molecular weight proteins (LMWPs) are known to be reabsorbed and catabolized primarily by the proximal tubular cells of the kidneys. As such, LMWPs might serve as drug carriers that release drugs site-specifically in the kidney. We tested this concept in vitro by coupling different drugs to the LMWP lysozyme both directly (amide bond) and via different spacers: oligopeptides (amide bond), (poly-)α-hydroxy acids (ester bond), and a pH sensitive cis-aconityl spacer (amide bond). The capability of the kidney to release the parent drug from such drug-spacer derivatives and drug-LMWP conjugates by enzymatic or chemical hydrolysis of the bond was tested by incubation experiments in renal cortex homogenates and lysosomal lysates. Directly coupled conjugates of terminal carboxyl group containing drugs and lysozyme were catabolized to single amino acids, but did not result in release of the parent drug. The amide bond between the drug and the final amino acid (lysine) appeared to be stable in the incubation milieu. Different oligopeptide spacers coupled to the drugs showed similar results: the oligopeptide itself was cleaved but the amide bond between the drug and different single amino acids remained untouched. Only amide bonds of derivatives of carboxylic drugs with peptide structures themselves were cleaved. Some of the directly coupled conjugates of terminal amino drugs and oligopeptides showed clear release of the parent drug whereas others were stable. Terminal amino drugs were rapidly released from an acid-sensitive cis-aconityl spacer. Terminal carboxyl group containing drugs were enzymatically released from their glycolic and lactic ester spacers at different rates. These kinds of drugs were also released as parent drug from LMWP conjugates with ester spacers like L-lactic acid. Increasing spacer length by intercalating a tetra(L-lactic acid) molecule between the drug and the protein further increased the extent and rate of drug release, indicating increased accessability of the bond to the enzymes. Terminal amino group containing drugs were rapidly generated as parent drug from LMWP conjugates using an acid-sensitive spacer. In addition the conjugates were found to be adequately stable in plasma, considering their rapid clearance from the bloodstream. It is concluded that LMWPs may indeed be of use as carriers for specific renal delivery of drugs, since renal cortex homogenates and lysosomal lysates are able to catabolize the protein and generate the parent drug from drug-LMWP conjugates bearing suitable spacers. The option of enzymatic release is limited by the narrow specificity of the lysosomal enzymes. This has profound implications for the synthesis of suitable conjugates, since the nature of the drug itself, the type of bond and also spacer length largely determine whether release of the parent drug will occur. Tailor-made spacers containing the correct mode of attachment and the right spacer length are required for this option. Chemical hydrolysis using acid-sensitive linkers, is suggested as a viable alternative approach.

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