28541-83-5 Usage
Description
4-METHYLUMBELLIFERYL BETA-D-MANNOPYRANOSIDE, also known as 4-MU-beta-D-Mannopyranoside, is a synthetic compound that serves as a substrate for various enzymes, particularly glycosidases. It is a white solid with unique chemical properties that make it useful in various applications across different industries.
Uses
Used in Enzyme Assays:
4-METHYLUMBELLIFERYL BETA-D-MANNOPYRANOSIDE is used as a substrate for mannosidase and N-acetyl-α-D-glucosaminidase enzymes. It is particularly useful in enzyme assays, where it helps in the detection and quantification of these enzymes' activities. The hydrolysis of 4-MU-beta-D-Mannopyranoside by these enzymes releases 4-methylumbelliferone, a fluorescent compound that can be easily measured, allowing for the assessment of enzyme activity.
Used in Analytical Chemistry:
4-METHYLUMBELLIFERYL BETA-D-MANNOPYRANOSIDE is used as an analytical reagent for studying biomass degradation by fungi. Its ability to act as a substrate for mannosidase enzymes makes it a valuable tool in understanding the enzymatic processes involved in the breakdown of complex carbohydrates in biomass, which has significant implications for biofuel production and other industrial applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-METHYLUMBELLIFERYL BETA-D-MANNOPYRANOSIDE is used as a research tool to study the inhibition and activity of glycosidase enzymes, which are often targeted in the development of drugs for various diseases, including lysosomal storage disorders and cancer. Its role in enzyme assays aids in the identification and optimization of potential drug candidates.
Used in Biotechnology:
In the biotechnology sector, 4-METHYLUMBELLIFERYL BETA-D-MANNOPYRANOSIDE is employed as a substrate for the study of enzyme kinetics, enzyme inhibition, and enzyme mechanism. Its use in these studies contributes to the development of biotechnological applications, such as the production of biofuels, bioplastics, and other bio-based materials derived from biomass.
Check Digit Verification of cas no
The CAS Registry Mumber 28541-83-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,4 and 1 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 28541-83:
(7*2)+(6*8)+(5*5)+(4*4)+(3*1)+(2*8)+(1*3)=125
125 % 10 = 5
So 28541-83-5 is a valid CAS Registry Number.
28541-83-5Relevant articles and documents
Based on 4 - methyl [...] synthesis method of a plurality of glycoside
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Paragraph 0084; 0085, (2018/10/11)
The invention discloses a method for synthesizing various glucosides on a basis of 4-methylumbelliferone. According to the invention, a glycosyl donor peracetyl saccharide and a glycosyl acceptor 4-methylumbelliferone are subjected to a glycosylation reaction under room temperature or under heating with dichloromethane or 1,2-dichloroethane as a solvent and with the combined effect of Lewis acid boron trifluoride ethyl ether and organic alkali triethylamine or pyridine; and protecting groups are removed, such that various glucosides based on 4-methylumbelliferone can be obtained. The glucosides include 4-methylumbelliferone-beta-D-glucopyranosiduronide, 4-methylumbelliferone-beta-D-glucopyranoside, 4-methylumbelliferone-beta-D-xylopyranoside, 4-methylumbelliferone-beta-D-ribofuranoside, 4-methylumbelliferone-alpha-D-galactopyranoside, and 4-methylumbelliferone-alpha-D-mannopyranoside. The method is simple, and can produce a beta or alpha single-configuration target. A glycosylation reaction yield can reach 17-93%.
CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY
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, (2012/06/15)
Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.
COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
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Page/Page column 69, 72, (2011/05/06)
The present invention encompasses compounds and methods for treating urinary tract infections.