285553-53-9

Upstream product

• 100-53-8 phenylmethanethiol 
• 51226-42-7 2,4,6-Trinitrobenzamide 
• 37841-25-1 1-cyano-2,4,6-trinitrobenzene 
• 292163-55-4 2-Benzylthio-4,6-dinitrobenzamide 

Downstream Products

• 906533-84-4 2,4-bis(2,2,2-trifluoroethoxy)-6-(benzylthio)benzonitrile 
• 354538-07-1 2,4-diazido-6-(benzylthio)benzonitrile 
• 906534-05-2 2,4-bis(2,2,2-trifluoroethoxy)-6-(benzylsulfinyl)benzonitrile 
• 447448-59-1 2-(benzylsulfonyl)-4,6-diphenoxybenzonitrile 
• 497141-72-7 2-(benzylsulfinyl)-4,6-diphenoxybenzonitrile 
• 906534-08-5 2,4-diazido-6-(benzylsulfonyl)benzonitrile 
• 496924-88-0 2,4-diazido-6-(benzylsulfinyl)benzonitrile 
• 309727-39-7 2-(benzylsulfonyl)-4,6-dimethoxybenzonitrile 
• 484049-76-5 2-(benzylsulfinyl)-4,6-dimethoxybenzonitrile 
• 447448-39-7 2-benzylthio-4,6-diphenoxybenzonitrile 
• 309286-37-1 2-benzylthio-4,6-dimethoxybenzonitrile 

Relevant academic research and scientific papers

Synthetic utilization of polynitroaromatic compounds. 4. Synthesis of nitro-free 4,6-disubstituted 3-aminobenzothiophene derivatives based on 2,4,6-trinitrobenzamide

A convenient synthesis of nitro-free 4,6-disubstituted 3-aminobenzothiophenes, their S-oxides and S,S-dioxides based on the available 2,4,6-trinitrobenzamide has been developed. The synthesis entails stepwise nucleophilic substitution of all nitro groups in the starting compound by S-, N-, and O-nucleophiles followed by Thorpe-Ziegler cyclization.

Chemistry of 2,4,6-trinitrobenzonitrile 1. Nitro group substitution in 2,4,6-trinitrobenzonitrile under the action of anionic nucleophiles. Factors favoring substitution of the ortho-nitro group

The direction of the nitro group substitution (the ratio of the ortho/para substitution) in 2,4,6-trinitrobenzonitrile under the action of anionic nucleophiles (MeO-, RS-, and N3-) as well as of HCl was studied.

Synthetic utilization of polynitroaromatic compounds. 1. S-derivatization of 1-substituted 2,4,6-trinitrobenzenes with thiols

Reactions of 1-R-2,4,6-trinitrobenenes (R = alkyl, protected aldehyde, aminocarbonyl, cyano groups, or isoxazole ring) with thiol salts were investigated. In most cases, these reactions gave a mixture of minor para and major ortho substitution products. Reactions of N,N-disubstituted 2,4,6-trinitrobenzamides with S-,O-, and N-nucleophiles afforded products of substitution of the p-nitro group exclusively. 1-Cyano-2,4,6-trinitrobenzene was found to be the most reactive and the least selective: all three nitro groups can be substituted using an excess of thiol salts. 2-R-4,6-dinitrobenzamides showed no regioselectivity under similar conditions to yield 1:1 mixtures of para and ortho isomers.