447448-39-7Relevant academic research and scientific papers
Synthetic utilization of polynitroaromatic compounds. 4. Synthesis of nitro-free 4,6-disubstituted 3-aminobenzothiophene derivatives based on 2,4,6-trinitrobenzamide
Zlotin, Sergei G.,Kislitsin, Pavel G.,Kucherov, Fedor A.,Gakh, Andrei A.
, p. 1109 - 1119 (2007/10/03)
A convenient synthesis of nitro-free 4,6-disubstituted 3-aminobenzothiophenes, their S-oxides and S,S-dioxides based on the available 2,4,6-trinitrobenzamide has been developed. The synthesis entails stepwise nucleophilic substitution of all nitro groups in the starting compound by S-, N-, and O-nucleophiles followed by Thorpe-Ziegler cyclization.
