285555-81-9

Upstream product

• 126361-27-1 (S)-(p-methoxybenzyloxy)propanal 
• 762-72-1 allyl-trimethyl-silane 
• 1730-25-2 allylmagnesium bromide 
• 144401-98-9 (S)-2-(4-methoxybenzyloxy)propionic acid ethyl ester 
• 220235-68-7 (-)-(2S)-methyl 2-(p-methoxybenzyloxy)propanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 105-13-5 4-Methoxybenzyl alcohol 
• 122151-36-4 (S)-2-O-(4'-methoxybenzyl)propan-1,2-diol 

Downstream Products

• 918819-61-1 (4R,5S)-1-benzyloxy-5-(4-methoxybenzyloxy)-4-tetrahydropyranyloxyhexane 
• 918819-57-5 (4R,5S)-5-(4-methoxybenzyloxy)-4-tetrahydropyranyloxy-1-hexene 

Relevant academic research and scientific papers

Synthesis of the northern hemisphere of epothilone A by a ten-membered ring closing metathesis reaction

The synthesis of the strained epothilone analog containing a ten- membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed

Stereodivergent approach in the protected glycal synthesis of L-vancosamine, L-saccharosamine, L-daunosamine and L-ristosamine involving a ring-closing metathesis step

In this paper, a new access to several chiral 3-aminoglycals as potential precursors for glycosylated natural products is reported from a common starting material, (?)-methyl-L-lactate. The stereodivergent strategy is based on the implementation of a ring

How stable are epoxides? A novel synthesis of epothilone B

Remarkable stability of the oxirane function is displayed over a number of synthetic operations in a novel synthesis of the antitumor compound epothilone B. The cis-epoxide, generated very early by dihydroxylation of an (E)-olefin, was resistant to more than ten synthetic steps under a wide variety of reaction conditions. TBS = tert-butyldimethylsilyl.

Epothilone B and its derivatives as novel antitumor drugs: Total and partial synthesis and biological evaluation

Microtubule stabilizing natural products, as exemplified by paclitaxel (taxolR), are being considered as novel drugs against malignant therapy resistent solid tumors. Among these compounds, epothilone B and some of its derivatives have emerged as particularly promising candidates for industrial development. The total and partial syntheses of these compounds are described in detail, and some of the most important recent results on their biological activity are discussed.