Synthesis of the northern hemisphere of epothilone A by a ten-membered ring closing metathesis reaction

Article abstract of DOI:10.1016/S0040-4039(99)00550-X

The synthesis of the strained epothilone analog containing a ten- membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed