285569-04-2

Basic information

• Product Name: 3-methyl-10-phenyl-10H-cyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4-dione
• Synonyms: 3-methyl-10-phenyl-10H-cyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4-dione
• CAS NO: 285569-04-2
• Molecular Weight: 303.32
• Mol File: 285569-04-2.mol

Chemical Properties

• CAS DataBase Reference: 3-methyl-10-phenyl-10H-cyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-10-phenyl-10H-cyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4-dione(285569-04-2)
• EPA Substance Registry System: 3-methyl-10-phenyl-10H-cyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4-dione(285569-04-2)

Safety Data

• Hazardous Substances Data: 285569-04-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 433282-78-1 9-methyl-cyclohepta[b]pyrimido[5,4-d]furan-8,10(9H)-dione 
• 3839-48-3 2-chlorotropone 
• 7269-95-6 6-anilino-3-methyluracil 

Relevant articles and documents

Alternative synthesis and novel oxidizing ability of 6,9-disubstituted cyclohepta[b]pyrimido[5,4-d]pyrrole-8(6H),10(9H)-dione derivatives

Synthesis of 6,9-disubstituted cyclohepta[b]pyrimido[5,4-d]pyrrole-8(6H), 10(9H)-diones 7a-g was accomplished by ring opening and ring closure sequences of 9-substituted cyclohepta[b]pyrimido[5,4-d]furan-8,10(9H)-dione derivatives induced by several amines. Furthermore, alternative synthetic methodology for compounds 7a-e was also accomplished by single-step reaction of 2-chlorotropone with 6-aminouracil derivatives under mild conditions. X-ray crystal analysis of 7a was carried out to clarify the structural characteristics. The properties of 7a-e were studied by the UV-vis spectra and reduction potentials (-1.24 to -1. 39 V vs Ag/AgNO3). Novel photo-induced oxidation reaction of 7a-d toward some amines under aerobic conditions was carried out to give the corresponding imines in more than 100% yield [based on compounds 7a-d], suggesting the oxidation reaction occurs in an autorecycling process.

Studies on pyrimidine-annulated heterocycles: A short synthesis of novel 6,9-disubstituted cyclohepta[b]pyrimido[5,4-d]pyrrole-8(6h),10(9H)-diones

A number of 6,9-disubstituted cyclohepta[b]pyrimido[5,4-d]pyrrole- 8(6H),10(9H)-dione derivatives have been synthesized in good to moderate yields by the reaction of 6-amino-3-methyluracil derivatives with 2- chlorotropone in an enamine-alkylation process