28561-64-0

Basic information

• Product Name: (2-amino-5-chlorophenyl)(4-methylphenyl)methanone
• Synonyms: (2-amino-5-chlorophenyl)(4-methylphenyl)methanone
• CAS NO: 28561-64-0
• Molecular Weight: 245.708
• Mol File: 28561-64-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-amino-5-chlorophenyl)(4-methylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-5-chlorophenyl)(4-methylphenyl)methanone(28561-64-0)
• EPA Substance Registry System: (2-amino-5-chlorophenyl)(4-methylphenyl)methanone(28561-64-0)

Safety Data

• Hazardous Substances Data: 28561-64-0(Hazardous Substances Data)

Upstream product

• 116035-66-6 N-(4-chloro-2-iodophenyl)acetamide 
• 104-87-0 4-methyl-benzaldehyde 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 34999-43-4 N-(4-chloro-2-(4-methylbenzoyl)phenyl)acetamide 

Downstream Products

• 1429095-72-6 [2-(2-azidobenzylideneamino)phenyl](4-tolyl)methanone 
• 35001-83-3 6-chloro-4-p-tolyl-1,4-dihydro-benzo[d][1,3]thiazine-2-thione 
• 35001-95-7 6-chloro-2-methylsulfanyl-4-p-tolyl-4H-benzo[d][1,3]thiazine 
• 91715-29-6 Sodium; [2-amino-5-chloro-3-(4-methyl-benzoyl)-phenyl]-acetate 
• 91714-27-1 5-Chloro-7-(4-methyl-benzoyl)-3-methylsulfanyl-1,3-dihydro-indol-2-one 
• 91714-28-2 5-Chloro-7-(4-methyl-benzoyl)-1,3-dihydro-indol-2-one 
• 488828-47-3 (2-amino-5-chloro-phenyl)-p-tolyl-methanol 

Relevant articles and documents

Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones

Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.

Improved synthesis of 2-amino-5-chlorophenyl-2'-pyrrylketone, a key intermediate in the synthesis of HIV Tat-antagonists

The reaction of a 2-phenylbenzoxazinone with pyrryl Grignard reagent is very efficient compared with that of a 2-methylbenzoxazinone. The title compound was prepared from 5-chloroanthranilic acid via the 2-phenylbenzoxazinone in 92% overall yield. This method was also successfully applied to the synthesis of 2-aminobenzophenones.