28561-64-0

Upstream product

• 116035-66-6 N-(4-chloro-2-iodophenyl)acetamide 
• 104-87-0 4-methyl-benzaldehyde 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 34999-43-4 N-(4-chloro-2-(4-methylbenzoyl)phenyl)acetamide 

Downstream Products

• 1429095-72-6 [2-(2-azidobenzylideneamino)phenyl](4-tolyl)methanone 
• 35001-83-3 6-chloro-4-p-tolyl-1,4-dihydro-benzo[d][1,3]thiazine-2-thione 
• 35001-95-7 6-chloro-2-methylsulfanyl-4-p-tolyl-4H-benzo[d][1,3]thiazine 
• 91715-29-6 Sodium; [2-amino-5-chloro-3-(4-methyl-benzoyl)-phenyl]-acetate 
• 91714-27-1 5-Chloro-7-(4-methyl-benzoyl)-3-methylsulfanyl-1,3-dihydro-indol-2-one 
• 91714-28-2 5-Chloro-7-(4-methyl-benzoyl)-1,3-dihydro-indol-2-one 
• 488828-47-3 (2-amino-5-chloro-phenyl)-p-tolyl-methanol 

Relevant academic research and scientific papers

Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones

Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.

Preparation of 2-arninpbenzophenones and polysubstituted quinolines through Sml2 promoted reductive cleavage of 3-aryl-2,1-benzisoxazoles

Promoted by SmI2, 3-aryl-2,1-benzisoxazoles underwent reductive cleavage of the N - O bond leading to 2-aminobenzophenones in high yields upon protonation. Otherwise, if ketones with active methylene group were added to the reaction mixture prior to protonation, the desired poly substituted quinolines could be obtained under mild conditions in a one-pot manner.

Improved synthesis of 2-amino-5-chlorophenyl-2'-pyrrylketone, a key intermediate in the synthesis of HIV Tat-antagonists

The reaction of a 2-phenylbenzoxazinone with pyrryl Grignard reagent is very efficient compared with that of a 2-methylbenzoxazinone. The title compound was prepared from 5-chloroanthranilic acid via the 2-phenylbenzoxazinone in 92% overall yield. This method was also successfully applied to the synthesis of 2-aminobenzophenones.