28567-96-6

Upstream product

• 98-86-2 acetophenone 
• 108714-18-7 3-(2-aminophenyl)-1-phenylprop-2-en-1-one 
• 103-72-0 phenyl isothiocyanate 
• 56-23-5 tetrachloromethane 
• 28181-30-8 4-ethoxy-3-phenyl-3,4-dihydro-1H-quinazoline-2-thione 

Relevant academic research and scientific papers

Catalyst-Free Chemoselective Synthesis of 3,4-Dihydroquinazoline-2-thiones and 2-Imino[1,3]benzothiazines

A solvent-controlled catalyst-free chemoselective reaction was developed. Both 3,4-dihydroquinazoline-2-thiones and 2-imino[1,3]benzothiazines could be efficiently constructed by the reaction of 2-amino chalcones with isothiocyanates via two different chemoselective reactions depending on the solvents. The reaction was modulated by the solvents to proceed via either aza-Michael addition or thia-Michael addition as the major reaction with excellent yields.