28586-66-5Relevant academic research and scientific papers
Synthesis of 3-substituted 3H-indol-3-ols by the reaction of 2-isocyanophenyl ketones with Grignard reagents
Kobayashi, Kazuhiro,Okamura, Yuta,Fukamachi, Shuhei,Konishi, Hisatoshi
experimental part, p. 7961 - 7964 (2010/10/19)
A facile method for the synthesis of 3-substituted 3H-indol-3-ols has been developed. Thus, 2-isocyanophenyl ketones are allowed to react with various Grignard reagents to give the corresponding desired indolol derivatives in generally fair to good yields. The formation of 3-aryl-2,3-dimethylindolin-3-ols by the reaction of 2-isocyanobenzophenones with 2 M amounts of methylmagnesium bromide is also reported.
