521270-77-9

Basic information

• Product Name: 2-ISOCYANO-5-CHLORBENZOPHENONE
• Synonyms: 2-ISOCYANO-5-CHLORBENZOPHENONE
• CAS NO: 521270-77-9
• Molecular Formula: C₁₄H₈ClNO
• Molecular Weight: 241.67
• Mol File: 521270-77-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ISOCYANO-5-CHLORBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOCYANO-5-CHLORBENZOPHENONE(521270-77-9)
• EPA Substance Registry System: 2-ISOCYANO-5-CHLORBENZOPHENONE(521270-77-9)

Safety Data

• Hazardous Substances Data: 521270-77-9(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 10352-28-0 N-(2-benzoyl-4-chlorophenyl)formamide 

Downstream Products

• 521270-80-4 4-chloro-1-isocyano-2-(2-methoxy-1-phenylethenyl)benzene 
• 92104-27-3 6-chloro-4-phenylquinazoline 3-oxide 
• 4015-28-5 6-chloro-4-phenylquinazoline 
• 70646-94-5 3-(2-Benzoyl-4-chloro-phenyl)-1,1-diethyl-thiourea 
• 67862-72-0 (5-chloro-2-isothiocyanatophenyl)phenylmethanone 
• 1346557-54-7 6-chloro-N-methyl-N,4-diphenyl-4H-3,1-benzothiazin-2-amine 
• 1346557-53-6 6-chloro-N,N-diethyl-4-phenyl-4H-3,1-benzothiazin-2-amine 
• 1346557-43-4 1-[4-chloro-2-hydroxy(phenyl)methyl]phenyl-3-methyl-3-phenylthiourea 
• 1346557-42-3 3-[4-chloro-2-hydroxy(phenyl)methyl]phenyl-1,1-diethyl-thiourea 
• 28586-66-5 5-chloro-2,3-diphenyl-3H-indol-3-ol 
• 1253396-28-9 5-chloro-2,2-dimethyl-3-phenylindolin-3-ol 
• 31576-77-9 6-chloro-4-phenyl-2-(piperidin-1-yl)quinoline 

Relevant articles and documents

Chemoselective double annulation of two different isocyanides: Rapid access to trifluoromethylated indole-fused heterocycles

An unprecedented chemoselective double annulation of α-trifluoromethylated isocyanides with o-acylaryl isocyanides has been developed. This new reaction provides a rapid, efficient, and complete atom-economic strategy for the synthesis of trifluoromethylated oxadiazino[3,2-α]indoles in a single operation from readily available starting materials. Isocyanide insertion into C=O double bonds is disclosed for the first time as indicated by the results of 18O-labeling experiment. A mechanism for this domino reaction is proposed involving chemoselective heterodimerization of two different isocyanides, followed by indole-2,3-epoxide formation and rearrangement.

Synthesis of 2,4-disubstituted quinolines by reactions of o-isocyano-β-methoxystyrene derivatives with organolithiums

Alkyl(or aryl)lithiums reacted efficiently with o-isocyano-β-methoxystyrene derivatives, prepared in three steps from o-aminophenyl ketones, to afford the corresponding 2,4-disubstituted quinolines in satisfactory yields.