521270-77-9

Upstream product

• 10352-28-0 N-(2-benzoyl-4-chlorophenyl)formamide 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 100-58-3 phenylmagnesium bromide 
• 5922-60-1 2-amino-5-chlorobenzonitrile 

Downstream Products

• 521270-80-4 4-chloro-1-isocyano-2-(2-methoxy-1-phenylethenyl)benzene 
• 31576-77-9 6-chloro-4-phenyl-2-(piperidin-1-yl)quinoline 
• 1253396-28-9 5-chloro-2,2-dimethyl-3-phenylindolin-3-ol 
• 28586-66-5 5-chloro-2,3-diphenyl-3H-indol-3-ol 
• 1346557-42-3 3-[4-chloro-2-hydroxy(phenyl)methyl]phenyl-1,1-diethyl-thiourea 
• 1346557-43-4 1-[4-chloro-2-hydroxy(phenyl)methyl]phenyl-3-methyl-3-phenylthiourea 
• 1346557-53-6 6-chloro-N,N-diethyl-4-phenyl-4H-3,1-benzothiazin-2-amine 
• 1346557-54-7 6-chloro-N-methyl-N,4-diphenyl-4H-3,1-benzothiazin-2-amine 
• 67862-72-0 (5-chloro-2-isothiocyanatophenyl)phenylmethanone 
• 70646-94-5 3-(2-Benzoyl-4-chloro-phenyl)-1,1-diethyl-thiourea 
• 4015-28-5 6-chloro-4-phenylquinazoline 
• 92104-27-3 6-chloro-4-phenylquinazoline 3-oxide 

Relevant academic research and scientific papers

Chemoselective double annulation of two different isocyanides: Rapid access to trifluoromethylated indole-fused heterocycles

An unprecedented chemoselective double annulation of α-trifluoromethylated isocyanides with o-acylaryl isocyanides has been developed. This new reaction provides a rapid, efficient, and complete atom-economic strategy for the synthesis of trifluoromethylated oxadiazino[3,2-α]indoles in a single operation from readily available starting materials. Isocyanide insertion into C=O double bonds is disclosed for the first time as indicated by the results of 18O-labeling experiment. A mechanism for this domino reaction is proposed involving chemoselective heterodimerization of two different isocyanides, followed by indole-2,3-epoxide formation and rearrangement.

A convenient synthesis of quinolines by reactions of o-isocyano-β- methoxystyrenes with nucleophiles

2,4-Disubstituted quinolines have been synthesized by reactions of o-isocyano-β-methoxystyrenes, which can be easily prepared from commercially available o-aminophenyl ketones in three steps, with alkyl(or aryl)lithiums in generally good yields. Subsequently, o-isocyano-β- methoxystyrenes have also proved to react efficiently with lithium dialkylamides to afford the corresponding 4-substituted N,N-dialkylquinolin-2-amines in satisfactory yields. Graphical Abstract.

Synthesis of 2,4-disubstituted quinolines by reactions of o-isocyano-β-methoxystyrene derivatives with organolithiums

Alkyl(or aryl)lithiums reacted efficiently with o-isocyano-β-methoxystyrene derivatives, prepared in three steps from o-aminophenyl ketones, to afford the corresponding 2,4-disubstituted quinolines in satisfactory yields.