285977-85-7

Usage

Uses

Used in Fragrance Industry:
(2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol is used as a fragrance ingredient for its pleasant, floral scent. It is incorporated into various consumer products such as perfumes, soaps, and cosmetics to enhance their overall scent profile.
Used in Pharmaceutical Industry:
(2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol is also used in the synthesis of pharmaceuticals and other organic compounds, contributing to the development of new medications and therapeutic agents.
However, it is important to note that (2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol may cause skin and eye irritation, and therefore should be handled with care during its use in these applications.

Upstream product

• 89044-48-4 2,5-dimethyl-2,3-dihydro-1H-inden-1-one 

Relevant academic research and scientific papers

PRO-FRAGRANCE COMPOUNDS

A compound of Formula (I) wherein R1 represents a C3 to C20 hydrocarbon group derived from a fragrant alcohol of formula R1OH or from a fragrant aryl aldehyde or ketone of Formula (II), wherein: R2 is, independently, hydrogen atom, hydroxyl group, acetoxy group, -O(C=O)CH(CH3), optionally substituted C1-C6 alkyl group or C1-C6 alkoxy group, wherein any two of R2 may form an optionally substituted 5 or 6 membered ring, and R1 represents a radical derived from a fragrant alcohol of formula R1OH or from a fragrant aldehyde or from a fragrant aryl aldehyde or ketone of formula (II). The compounds are useful for example as a precursor for the prolonged delivery or release of fragrant compounds such as fragrant alcohols or aldehydes.

Synthesis and optical resolution of the floral odorant (±)-2,3- dihydro-2,5-dimethyl-1H-indene-2-methanol, and preparation of analogues

The title compound (±)-1, a recently discovered, valuable, floral-type odorant, has been synthesized by a straightforward procedure (Scheme 1), To determine the properties of the enantiomers of 1, their separation by preparative HPLC and the determination of their absolute configuration by X-ray crystallography were carried out (Figure). Furthermore, the analogues 2-6 were synthesized, either from differently methylated 2-methylin-dan-1-ones (Schemes 2 and 3) or, in the case of the 2,4,6-trimethylated homologue 6, by a completely different synthetic approach (Scheme 4). An evaluation of (+)-(S)-1, (-)-(R)-1, and (±)-1 showed only minor differences in terms of odor (Table).