89044-48-4

Usage

Uses

Used in Fragrance Industry:
1H-Inden-1-one, 2,3-dihydro-2,5-dimethylis used as a fragrance ingredient in perfumes and personal care products. Its floral and woody scent profile makes it a valuable addition to the formulation of various fragrances, enhancing the overall sensory experience of these products.
Used in Pharmaceutical Industry:
1H-Inden-1-one, 2,3-dihydro-2,5-dimethylis utilized in the synthesis of pharmaceuticals, serving as a key building block for the development of new drugs. Its unique chemical structure allows for the creation of novel therapeutic agents with potential applications in various medical fields.
Used as a Chemical Intermediate:
1H-Inden-1-one, 2,3-dihydro-2,5-dimethylis employed as a chemical intermediate in the manufacturing of other organic compounds. Its versatile chemical properties enable it to be a crucial component in the synthesis of a wide range of specialty chemicals.
Used in Material Science:
1H-Inden-1-one, 2,3-dihydro-2,5-dimethylhas potential applications in the development of new materials, where its unique properties can be harnessed to create innovative products with enhanced performance characteristics.
Overall, 1H-Inden-1-one, 2,3-dihydro-2,5-dimethylis a multifaceted chemical compound with a broad spectrum of applications in various industries, including fragrances, pharmaceuticals, chemical intermediates, and material science, due to its distinctive odor and chemical properties.

Upstream product

• 859192-05-5 α-methyl-β-(3-methylphenyl)propionic acid 
• 620-13-3 1-bromomethyl-3-methyl-benzene 
• 94430-87-2 diethyl (3-methylphenylmethyl)methylmalonate 
• 959631-88-0 methyl 2-allyl-4-methylbenzoate 
• 87808-49-9 2-bromo-4-methyl-benzoic acid methyl ester 

Downstream Products

• 285978-03-2 2-(hydroxymethyl)-2,5-dimethyl-2,3-dihydro-1H-inden-1-one 
• 140841-04-9 3,4-dihydro-3,6-dimethyl-2H-1-benzopyran-2-one 
• 285977-87-9 (+)-(2S)-2,3-dihydro-2,5-dimethyl-1H-indene-2-methanol 
• 285977-85-7 (+/-)-2,3-dihydro-2,5-dimethyl-1H-indene-2-methanol 

Relevant academic research and scientific papers

Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles

While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross-coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)?O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl-retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used.

Synthesizing method of indanone compound

The invention discloses a synthesizing method of an indanone compound. The synthesizing method comprises the following steps of respectively adding a catalyst and an antioxidant into a reaction bottle, then adding a compound shown in a formula (2), adding a solvent, and reacting for 2 to 6h at the temperature of 70 to 120 DEG C under the argon protection atmosphere, so as to obtain the indanone compound, wherein the catalyst is selected from any one of Cu(OAc)2, CuCl2 (copper (II) chloride), CuBr2 (copper (II) bromide), CuO (copper oxide), CuF2 (copper fluoride), Cu(OTf) 2, Cu(OH)2 (copper hydroxide), Cu(NO3)2 (copper nitrate), CuCl (copper chloride), CuBr (copper bromide), CuI (cuprous iodide) and Cu2O (cuprous oxide); the oxidant is tert-butyl hydroperoxide; the solvent is toluene. The synthesizing method has the advantages that a novel concept of the indanone compound is provided; the copper catalyst is used, the price of copper is low, the reserve amount is rich, the environment-friendly effect is realized, and the hydroacylation reaction catalyzed by copper meets the requirements of green chemistry.

Rh-catalyzed reagent-free ring expansion of cyclobutenones and benzocyclobutenones

Here we report a reagent-free rhodium-catalyzed ring-expansion reaction via C-C cleavage of cyclobutenones. A variety of poly-substituted cyclopentenones and 1-indanones can be synthesized from simple cyclobutenones and benzocyclobutenones. The reaction condition is near pH neutral without additional oxidants or reductants. The potential for developing a dynamic kinetic asymmetric transformation of this reaction has also been demonstrated. Further study supports the proposed pathway involving Rh-insertion into the cyclobutenone C-C bond, followed by β-hydrogen elimination, olefin insertion and reductive elimination.

Halogen substituted metallocene compounds for olefin polymerization

A metallocene compound is represented by the formula (1): wherein: M is a Group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom, preferably a Group 4 transition metal atom selected from titanium, zirconium or hafnium; E is a substituted or unsubstituted monocyclic or polycyclic arenyl ligand pi-bonded to M; A is a substituted or unsubstituted polycyclic arenyl ligand that is pi-bonded to M and has a different ring structure than the E ligand; at least one of the A and E ligands includes at least one halogen substituent directly bonded to an sp2 carbon at a bondable ring position; Y is a bridging group containing at least one Group 13, 14, 15, or 16 element and any single position of the ring structure of A and to any single position of the ring structure of E; and y is zero or 1, indicating the absence (y=0) or presence (y=1) of Y; and each X is a univalent anionic ligand, or two X are joined and bound to the metal atom to form a metallocycle ring, or two X are joined to form a chelating ligand, a diene ligand, or an alkylidene ligand; provided that when E is an unsubstituted cyclopentadienyl ligand, either y is one or A is not 2-bromofluorenyl or 2,7-dibromofluorenyl.

Carbon-13 Nuclear Magnetic Resonance Spectra of Pterosin-Sesquiterpenes and Related Indan-1-one Derivatives

Methyl derivatives of indan-1-one were prepared as models to aid in interpreting the carbon-13 nuclear magnetic resonance ((13)C-NMR) spectra of pterosin-sesquiterpenes which were isolated from bracken fern, Pteridium aquilinum var. latiusculum.The chemical shifts of the carbons of the methylindan-1-ones were assigned by the proton decoupling technique.All the (13)C-NMR signals of the pterosin-sesquiterpenes were assigned by means of selective proton decouplings, and from the (13)C-(1)H long-range couplings and (13)C chemical shifts of the model compounds.Keywords - indan-1-one derivative; methylindan-1-one; pterosin-sesquiterpene; methylindan-1-one synthesis; (1)H-NMR; (13)C-NMR; selective decoupling; C-H decoupling