285997-64-0

Upstream product

• 109-80-8 1.3-propanedithiol 
• 285997-57-1 (1R,3R)-2-[(2R,4R)-4-Ethyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-1,3-diphenyl-propane-1,3-diol 

Downstream Products

• 285997-71-9 (4R,6R)-5-[1,3]Dithian-2-yl-2,2-dimethyl-4,6-diphenyl-[1,3]dioxane 
• 240423-62-5 ((4R,6R)-2,2-Dimethyl-4,6-diphenyl-[1,3]dioxan-5-yl)-methanol 
• 240423-65-8 (4R,6R)-2,2-Dimethyl-4,6-diphenyl-[1,3]dioxane-5-carbaldehyde 

Relevant academic research and scientific papers

Enantio- and diastereoselective synthesis of (protected) 2-formyl- and 2-(hydroxymethyl)-1-phenylalkane-1,3-diols from chiral 2-methoxy-3-tosyl-1,3- oxazolidines by subsequent asymmetric formylation and aldolization

Trimethylsilyl enol ethers are successively converted into chirally protected α-formyl ketones by asymmetric formylation with the 2-methoxy-1,3- oxazolidine 2, transformed into the corresponding, thermodynamically determined (Z)-TMS enol ethers, and then are allowed to condense with aldehydes. All steps proceed with high stereoselectivity. Some synthetic options, arising from the three differentiated oxygen functionalities in the intermediates 8 are illustrated for the title target compounds.