286010-04-6Relevant articles and documents
5-deoxy, 12-deoxy, 5,12-bisdeoxy, and 4,5,12-trisdeoxy anthracyclines: Synthesis of new analogues of daunorubicin and doxorubicin by controlled deoxygenation of the C-ring
Cameron, Donald W.,Feutrill, Geoffrey I.,Griffiths, Peter G.
, p. 25 - 40 (2007/10/03)
Hydrogenation of the anthracyclines daunorubicin (1) and doxorubicin (2) gave selective deoxygenation at position 5. Hydride reduction of (1) and (2) gave complementary regiocontrol, leading to 12-deoxygenation or 5,12-bisdeoxygenation. This chemistry all