28610-03-9

Upstream product

• 4428-98-2 N-cyanomethanimidic acid ethyl ester 
• 132685-75-7 isobutyrophenone diaminomethylenehydrazone 
• 4922-98-9 3-phenyl-1H-1,2,4-triazol-5-amine 
• 28609-98-5 5-amino-1-guanyl-3-phenyl-1,2,4-triazole 
• 122-51-0 orthoformic acid triethyl ester 
• 420-04-2 CYANAMID 
• 1428770-64-2 N¹,N¹-dimethyl-N²-[3-phenyl-1,2,4-triazol-5-yl]formamidine 

Relevant academic research and scientific papers

A novel multicomponent microwave-assisted synthesis of 5-aza-adenines

A novel multicomponent strategy for the efficient synthesis of 5-aza-adenines was developed. 5-Aza-adenines were prepared in a one-pot fashion from 5-amino-1,2,4-triazoles, cyanamide and triethyl orthoformate under microwave irradiation. The operational simplicity, efficiency and accessibility of this method make it highly attractive for the generation of bioactive compound libraries.

A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide

The amino substituted triazine ring was annelated to aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of azolylformamidines in the reaction of aminoazoles with N,N-dimethylformamide dimethyl acetal followed by the triazine ring closure with cyanamide affording therefore fused aminotriazines.

Synthesis of Nitrogen-Containing Heterocycles. 5. A New Route to 5-Amino-triazolotriazine Derivatives

Treatment of certain diaminomethylenehydrazones 1 of aromatic carbonyl compounds with ethyl N-cyanoimidate (2) in acetonitrile in the presence of a tertiary amine at room temperature gives the corresponding amino(N-cyanoiminomethyl)aminomethylenehydrazone

Reaction of N-Cyanoformimidates with some Heterocyclic Compounds. A New Synthesis of 5-Azaadenine and Related Compounds

3-Amino-1,2,4-triazoles and 2-aminobenzimidazole were reacted with N-cyanoimidates to give 5-amino-1,2,4-triazolo-1,3,5-triazines (5-azaadenines) and 4-aminobenzimidazo-1,3,5-triazines, respectively.The structures of the compounds obtained were confirmed through the comparison with some of the possible isomers prepared by independent methods.