2862-10-4Relevant academic research and scientific papers
Molecular probes of DNA bulges: Functional assay and spectroscopic analysis
Jones, Graham B.,Lin, Yiqing,Xiao, Ziwei,Kappen, Lizzy,Goldberg, Irving H.
, p. 784 - 790 (2007/10/03)
Bulged structures in DNA and RNA have been linked to biomolecular processes involved in numerous diseases, thus probes with affinity for these nucleic acid targets would be of considerable utility to chemical biologists. Herein, we report guided chemical
Synthesis of β(1-4)-Linked Disaccharides of N-Acetylglucosamine and3 N-Acetylmuramic Acid by Their Direct Condensation
Kusumoto, Shoichi,Imoto, Masahiro,Oguki, Tsuyoshi,Shiba, Tetsuo
, p. 1419 - 1424 (2007/10/02)
As a basic study in the synthetic approach to immunoactive cell wall peptid3oglycan whose backbone is a β(1-4)-linked saccharide of alternating glucosamine and3 muramic acid, methods for the direct condensation of these sugar components were studied and O-(N-acetyl-β-muramyl)-(1->4)-N-acetyl-D-glucosamine and O-(N-acetyl-β-D-glucosaminyl)-(1->4)-N-acetylmuramic acid were synthesized.In the synthesis of the latter disaccharide, previous formation of an ester bond between the carboxyl group of muramic acid and the 6-hydroxyl group of glucosamine proved to facilitate the glycoside bond formation between these sugar moieties.
Chemical synthesis of 1-dephospho derivative of escherichia coli lipid A
Kusumoto,Yoshimura,Imoto,Shimamoto,Shiba
, p. 909 - 912 (2007/10/02)
1-Dephospho E. coli lipid A (3) was synthesized and shown to be identical with the corresponding derivative isolated from bacterial cells. This provides the unequivocal evidence supporting the structure of E. coli lipid A (2) recently proposed by us.
