2864-27-9Relevant academic research and scientific papers
Michael addition of pyrimidine derivatives with acrylates catalyzed by lipase TL im from Thermomyces lanuginosus in a continuous-flow microreactor
Du, Li-Hua,Ling, Hui-Min,Luo, Xi-Ping
, p. 7770 - 7773 (2014)
Lipase-catalyzed Michael addition of pyrimidine derivatives to acrylates in a continuous-flow microreactor is described. The influence of the structure of the Michael acceptor and the corresponding donor on the enzymatic addition was also investigated. The important features of this method include mild reaction conditions, short reaction times (30 min) and high yields.
Microwave-promoted Michael addition in neat water: A rapid, efficient and green method for the preparation of acyclic nucleosides
Qu, Gui-Rong,Zhang, Zhi-Guang,Geng, Ming-Wei,Xia, Ran,Zhao, Lin,Guo, Hai-Ming
, p. 721 - 724 (2007)
Syntheses of acyclic nucleosides were achieved in water with the aid of microwave irradiation, providing a rapid, efficient and convenient method for the preparation of acyclic nucleosides in high yields. Georg Thieme Verlag Stuttgart.
The attempts of the cyano group reduction in 1-cyanoethyl 5-substituted uracil derivatives
Boncel,Walczak
, p. 2151 - 2156 (2008/09/18)
A variety of reductants for the reduction of 1-cyanoethyl-5-substituted uracil derivatives has been examined. Commonly used reductants, borane dimethyl sulphide complex, ammonium formate and sodium borohydride were applied. For the most investigated 5-substituted uracil derivatives the reduction with sodium borohydride has shown the highest efficiency when nickel(II) chloride as a catalyst has been applied. The reactions were performed in methanol at decreased temperature in the presence of di-tert-butyl carbonate as a "trapping" agent. The Boc-protected 1-(3-aminopropyl)pyrimidine-2, 4(1H,3H)-diones were synthesized in moderate to high yields.
Cobalt-mediated [2+2+2] cycloadditions of pyrimidine derivatives to alkynes
Pelissier, Helene,Rodriguez, Jean,Vollhardt, K. Peter C.
, p. 3549 - 3561 (2007/10/03)
The scope and limitations of the cobalt-mediated [2+2+2] cycloaddition of pyrimidine derivatives to alkynes has been investigated. The 5,6-double bond of these heterocyclic nuclei has been found to participate in an entirely intermolecular fashion to generate chemo- and stereoselectively novel, fused and substituted 5,6-dihydropyrimidine cobalt complexes, which upon oxidative demetallation liberate the corresponding new heterocyclic ligand. On the other hand, 1-alkynyl pyrimidines have been found to be suitable partners in the cocyclization with disubstituted alkynes, such as bis(trimethylsilyl)acetylene (BTMSA) or dimethyl 2-butyn-1,4-dioate (DMAD), to allow the direct preparation of hitherto unknown dihydropyrido[3,2-ij]quinazoline cobalt complexes. Effects of the substitution on the pyrimidine nucleus, the cocyclization partner, the complex auxiliary, and the reaction conditions were examined, and in some cases competing pathways that lead to [CpCo(cyclobutadienes)], cyclopentadienone complexes, and compounds that arise from a C-H activation-type reaction were observed.
CHARACTERISATION OF ADDUCTS OF NUCLEIC BASES AND ACRYLIC MONOMERS
Crippa, Sergio,Di Gennaro, Patrizia,Lucini, Ruggero,Orlandi, Marco,Rindone, Bruno
, p. 197 - 203 (2007/10/02)
Spectral data and thermodynamic calculations of adducts of purines (guanine, adenine), or pyrimidines (thymine, uracil) with acrylic monomers (acrylonitrile, ethyl acrylate, and ethyl crotonate) are reported.Purine adducts derive from attack at N-7 and N-9, and pyrimidine adducts derive from attack at N-1.Acrylonitrile forms also N-1, N-3 bis adducts with pyrimidines.Structural assignment was by 1H and 13C NMR and using COSY-RELAY and NOE effects.Force-field calculations indicated the most stable conformations of the reaction products.
