2864-50-8

Usage

Uses

Used in Pharmaceutical Applications:
Cholesteryl sodium sulfate is used as a pharmaceutical agent for its ability to form nonconventional liposomes. This allows researchers to study cellular membrane properties and develop novel drug delivery systems.
Used in Research and Development:
In the field of research and development, Cholesteryl sodium sulfate is used as a key component in the study of cell membranes, lipid metabolism, and the development of new therapeutic approaches.
Used in Industrial Applications:
Cholesteryl sodium sulfate is used in the industrial production of gallstones, which are then utilized for various purposes, such as the development of new medical treatments and the study of gallstone formation and prevention.
Chemical Properties:
Cholesteryl sodium sulfate is a white to off-white solid, which makes it suitable for various applications in different industries.

InChI:InChI=1/C27H46O4S.Na/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5;/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30);/q;+1/p-1/t19-,21+,22+,23-,24+,25+,26+,27-;/m1./s1

Upstream product

• 1256-86-6 cholesterol 3-sulfate 
• 57-88-5 cholesterol 
• 3381-54-2 cholesterol mesylate 

Downstream Products

• 57-88-5 cholesterol 
• 57-88-5 cholesterol 
• 604-35-3 Cholesteryl acetate 

Relevant academic research and scientific papers

UPLC–MS/MS identification of sterol sulfates in marine diatoms

Diatoms are unicellular eukaryotic organisms that play a key ecological and biogeochemical role in oceans as major primary producers. Recently, these microalgae have also attracted interest as a promising source of functional products with widespread relevance. Progress in the knowledge of cell and molecular biology of diatoms is envisaged as a key step to understanding regulation of their life cycle in marine environments as well as facilitating their full and profitable exploitation by biotechnological platforms. Recently, we identified sterol sulfates (StS) as regulatory molecules of cell death in the diatom Skeletonema marinoi. As these compounds may have a general role in diatom physiology and chemical signals in aquatic systems, we investigated a suitable tool for their analysis in laboratory and field samples. Herein, we describe a sensitive, fast, and efficient ultra performance liquid chromatography–mass spectrometry (UPLC–MS) method for qualitative and quantitative analysis of StS from crude extract of diatoms and other microalgae. The method was applied to 13 different strains of our collection of marine protists. This first study suggested a species-specific distribution of StS and identified the sulfated derivatives of 24-methylene cholesterol and 24-methyl cholesterol as the most common members in diatoms.

Sterol Sulfates and Sulfotransferases in Marine Diatoms

Sterol sulfates are widely occurring molecules in marine organisms. Their importance has been so far underestimated although many of these compounds are crucial mediators of physiological and ecological functions in other organisms. Biosynthesis of sterol sulfates is controlled by cytosolic sulfotransferases (SULTs), a varied family of enzymes that catalyze the transfer of a sulfo residue (–SO3H) from the universal donor 3′-phosphoadenosine-5′-phosphosulfate to the hydroxyl function at C-3 of the steroid skeleton. The absence of molecular tools has been the main impediment to the development of a biosynthetic study of this class of compounds in marine organisms. In fact, there is very limited information about these enzymes in marine environments. SULT activity has, however, been reported in several marine species, and, recently, the production of sterol sulfates has been linked to the control of growth in marine diatoms. In this chapter, we describe methods for the study of sterol sulfates in this lineage of marine microalgae. The main aim is to provide the tools useful to deal with the biosynthesis and regulation of these compounds and to circumvent the bottleneck of the lack of molecular information. The protocols have been designed for marine diatoms, but most of the procedures can be used for other marine organisms.

CRYSTALLINE AND LIQUID CRYSTALLINE 25-HYDROXY-CHOLEST-5-EN-3-SULFATE SODIUM AND METHODS FOR PREPARING SAME

Crystalline and liquid crystalline forms of 25HC3S sodium are described herein. The disclosure includes Forms I, II, III, V, IX, XI, and XIII of 25HC3S sodium and combinations thereof. Pharmaceutical formulations of said forms, or combinations thereof, and methods of treating or preventing disease such as hypercholesterolemia, hypertriglyceridemia, and conditions related to fat accumulation and inflammation (e.g., non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, and atherosclerosis) are further disclosed herein. Methods for preparing 25HC3S are also provided

Preparation method of medicinal sodium cholesteryl sulfate

The invention provides medicinal sodium cholesteryl sulfate and a preparation method thereof. By controlling the addition proportion of cholesterol, sulfamic acid and sodium hydroxide, the content ofsodium ions in the product is within the range of 4.5%-4.9%, it is guaranteed that the final reaction product is basically pure sodium cholesteryl sulfate and hardly contains cholesterol sulfate, anda qualified raw material is provided for safely and effectively applying sodium cholesteryl sulfate.