28640-26-8Relevant academic research and scientific papers
Trisulfur-Radical-Anion-Triggered C(sp2)-H Amination of Electron-Deficient Alkenes
Nguyen, Khang X.,Nguyen, Thao T.,Nguyen, Tung T.,Pham, Hoai T. B.,Pham, Phuc H.,Phan, Nam T. S.,Wang, Haobin,Yang, Chou-Hsun
, p. 9751 - 9756 (2020)
A trisulfur-radical-anion (S3˙-)-triggered C(sp2)-H amination of α,β-unsaturated carbonyl derivatives with simple amines has been demonstrated. This protocol provides convenient access to a variety of synthetically valuable N-unprotected and secondary β-enaminones with absolute Z selectivity and tertiary β-enaminones with E selectivity. Mechanistic probe and electronic structure theory calculations suggest that S3˙- initiates the nucleophilic attacks via a thiirane intermediate.
RING CLEAVAGE OF N-ALKYLISOXAZOLIUM SALTS BY LITHIUM DIALKYLCUPRATES: SYNTHESIS OF β-ENAMINOKETONES
Alberola, A.,Gonzalez, A. M.,Laguna, M. A.,Pulido, F. J.
, p. 673 - 680 (2007/10/02)
N-Alkylisoxazolium salts undergo ring cleavage when treated with lithium dialkylcuprates to give β-enaminoketones in high yields.
