286455-91-2

Upstream product

• 67-56-1 methanol 
• 119987-21-2 (E)-methyl 2-diazo-4-phenylbut-3-enoate 
• 112068-21-0 rac-(E)-2-hydroxy-4-phenyl-3-butenoic acid methyl ester 
• 74-88-4 methyl iodide 
• 107969-78-8 methyl benzylidenepyruvate 
• 1392838-19-5 methyl (E)-2,2-dimethoxy-4-phenyl-3-butenoate 

Downstream Products

• 917368-83-3 (R,S)-2-methoxy-4-phenylbut-3-enoic acid 

Relevant academic research and scientific papers

Chiral catalyst enhancement of diastereocontrol for O-H insertion reactions of styryl- and phenyldiazoacetate esters of pantolactone

The chiral dirhodium(II) catalyst Rh2(MEAZ)4 increases diastereocontrol for intermolecular O-H insertion reactions of diazo esters having a chiral auxiliary over that achieved with Rh2(OAc)4.

Lewis acid-promoted reaction of β,γ-unsaturated α,α-dimethoxy esters with silyl nucleophiles

The Lewis acid-promoted reaction of β,γ-unsaturated α,α-dimethoxy esters, which are easily prepared by the acetalization of β,γ-unsaturated α-keto esters, with silyl nucleophiles is presented. By employing trimethylsilyl enolate and allyltrimethylsilane as nucleophiles, the BF3-promoted reactions of a series of β,γ-unsaturated α,α-dimethoxy esters bearing aromatic and aliphatic substituents proceeded at the γ-position in an SN2′ manner to furnish γ-substituted α,β-unsaturated α-methoxy esters in good yields with high regioselectivity. In contrast, the reaction using trimethylsilyl cyanide predominantly occurred at the α-position, and the reaction of silyl hydride resulted in a mixture of α- and γ-regioisomers in favor of the γ-substitution products.

BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES

The present invention relates to butenoic acid derivatives of the formula (I) in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions c

Regiochemistry of molybdenum-catalyzed O-H insertions of vinylcarbenoids

Molybdenum-catalyzed decomposition of vinyldiazoacetates generates vinylcarbenoids that preferentially react with alcohols at the vinylogous position of the vinylcarbenoid rather than at the carbenoid site.