28683-48-9Relevant academic research and scientific papers
NEW TETRACYCLIC COMPOUNDS
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Page/Page column 255, (2009/05/30)
This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3- b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
Synthesis and biological evaluation of novel γ-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists
Ivachtchenko, Alexandre V.,Frolov, Eugene B.,Mitkin, Oleg D.,Kysil, Volodymyr M.,Khvat, Alexander V.,Okun, Ilya M.,Tkachenko, Sergey E.
supporting information; experimental part, p. 3183 - 3187 (2010/03/03)
Synthesis, biological evaluation and structure-activity relationships for a series of novel γ-carboline analogues of Dimebon are described. Among the studied compounds, γ-carbolines 3{8} and 3{14} have been identified as potent small molecule a
