28691-43-2

Basic information

• Product Name: Benzenemethanol, 4-methyl-a-(nitromethyl)-
• CAS NO: 28691-43-2
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Mol File: 28691-43-2.mol
• Article Data: 76

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-methyl-a-(nitromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-methyl-a-(nitromethyl)-(28691-43-2)
• EPA Substance Registry System: Benzenemethanol, 4-methyl-a-(nitromethyl)-(28691-43-2)

Safety Data

• Hazardous Substances Data: 28691-43-2(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 104-87-0 4-methyl-benzaldehyde 
• 106-42-3 para-xylene 
• 62968-73-4 2-nitro-1-(p-tolyl)ethan-1-one 

Downstream Products

• 53360-85-3 2-amino-1-(4-methylphenyl)ethanol 
• 778617-30-4 (S)-tert-butyl-(2-hydroxy-2-p-tolylethyl)carbamate 
• 7559-36-6 4-methyl-β-nitrostyrene 
• 104-87-0 4-methyl-benzaldehyde 
• 1336918-23-0 (R)-2-nitro-1-(p-tolyl)ethyl acetate 

Relevant articles and documents

Studies of the Henry reaction catalyzed by Cu-O and Zn-O complexes with dimethoxysilane-bridged derivatives

Dimethyldimethoxysilane, methylphenyldimethoxysilane, and diphenyldimethoxysilane have been synthesized by a one-step, simple method and used as catalysts in the Henry reaction with Cu(OAc)2.H2O and Zn(OAc)2.2H2O, affording 60-96% conversion under the optimum catalytic conditions. Springer Science+Business Media B.V. 2010.

Synthesis of DPA-triazole structures and their application as ligand for metal catalyzed organic reactions

In this work, the use of DPA-triazole (DPA = dipicolylamine) molecules as ligands for metal catalyzed organic reactions has been investigated. A small library of ligands has been prepared by a CuAAC (click reaction) between propargyl-DPA and different azi

Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles

A metal-free, mild and chemodivergent transformation involving nitroalkanes has been developed. Under optimized reaction conditions, in the presence of trichlorosilane and a tertiary amine, aliphatic nitroalkanes were selectively converted into amines or nitriles. Furthermore, when chiral β-substituted nitro compounds were reacted, the stereochemical integrity of the stereocenter was maintained and α-functionalized nitriles were obtained with no loss of enantiomeric excess. The methodology was successfully applied to the synthesis of chiral β-cyano esters, α-aryl alkylnitriles, and TBS-protected cyanohydrins, including direct precursors of four active pharmaceutical ingredients (ibuprofen, tembamide, aegeline and denopamine).