286930-76-5Relevant articles and documents
Unusual behaviour of N-cinnamoyl-2-hydroxy-2- (trifluoromethyl)arylethylamines in Pictet-Gams cyclization. Synthesis of 2- styryl-5-aryl-5-trifluoromethyl-2-oxazolines
Poszavacz, Laszlo,Simig, Gyula
, p. 343 - 348 (2007/10/03)
Cyclization of N-acyl-2-hydroxy-2-(trifluoromethyl)arylethylamines 4 under Pictet-Gams conditions afforded 2-oxazolines 5 instead of the expected isoquinolines 6. The effect of the trifluoromethyl group on the result of the reaction is discussed.