286956-31-8

Basic information

• Product Name: Methanone, [4-(4-chlorophenyl)-1H-pyrrol-3-yl](5-chloro-2-thienyl)-
• CAS NO: 286956-31-8
• Molecular Formula: C15H9Cl2NOS
• Molecular Weight: 322.215
• Mol File: 286956-31-8.mol

Chemical Properties

• CAS DataBase Reference: Methanone, [4-(4-chlorophenyl)-1H-pyrrol-3-yl](5-chloro-2-thienyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [4-(4-chlorophenyl)-1H-pyrrol-3-yl](5-chloro-2-thienyl)-(286956-31-8)
• EPA Substance Registry System: Methanone, [4-(4-chlorophenyl)-1H-pyrrol-3-yl](5-chloro-2-thienyl)-(286956-31-8)

Safety Data

• Hazardous Substances Data: 286956-31-8(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 6310-09-4 2-acetyl-5-chlorothiophene 
• 96583-49-2 (2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-chlorophenyl)prop-2-en-1-one 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 

Relevant articles and documents

The pyrrole moiety as a template for COX-1/COX-2 inhibitors

Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a biological system using bovine PMNLs as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of the concentration of arachidonic acid metabolites was performed by HPLC for COX-1 and RIA for COX-2. Variation of the substitution pattern led to a series of active compounds which showed inhibition for COX-1 and COX-2. Structural requirements for the development of COX-1/COX-2 inhibitors are discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.