28707-60-0Relevant academic research and scientific papers
Polyaza Cavity Shaped Molecules. Annelated Derivatives of 2-(2'-Pyridyl)-1,8-naphthyridine and 2,2'-Bi-1,8-naphthyridine
Thummel, Randolph P.,Lefoulon, Francois,Cantu, David,Mahadevan, Ramanathan
, p. 2208 - 2212 (1984)
A two-step method is presented for the oxidation of the 2-methylene position of 2,3-cycloalkenopyridines.The pyridyl ketones thus obtained may be reacted with 2-aminonicotinaldehyde to yield 3,3'-annelated derivatives of 2-(2'-pyridyl)-1,8-naphthyridine.T
Kilogram-scale synthesis of the CXCR4 antagonist GSK812397
Boggs, Sharon,Elitzin, Vassil I.,Gudmundsson, Kristjan,Martin, Michael T.,Sharp, Matthew J.
scheme or table, p. 781 - 785 (2010/04/22)
An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiomeric
QUINOLYNYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS
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Page/Page column 14; 15, (2008/12/07)
Disclosed herein is a compound of the formula (I):(I).Therapeutic methods, compositions and medicaments related thereto are also disclosed.
7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline
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Page/Page column 7-8, (2008/06/13)
A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
A facile synthesis of α,α′-bis(substituted-benzylidene)-cycloalkanones and substituted-benzylidene heteroaromatics: utility of NaOAc as a catalyst for aldol-type reaction
Motiur Rahman,Jeong, Byeong-Seon,Kim, Dong Hyeon,Park, Jung Ki,Lee, Eung Seok,Jahng, Yurngdong
, p. 2426 - 2431 (2007/10/03)
Utility of NaOAc in glacial HOAc as a catalyst for aldol-type condensation reactions was examined. Reactions of cycloalkanones and selected heteroaromatics with various aldehydes in the presence of NaOAc in glacial HOAc provided α,α′-bis(substituted-benzylidene)cycloalkanones and substituted-benzylidene heteroaromatics, respectively, in good yields.
Synthesis, characterization and electroluminescence properties of new iridium complexes based on cyclic phenylvinylpyridine derivatives: Tuning of emission colour and efficiency by structural control
Takizawa, Shin-Ya,Sasaki, Yuka,Akhtaruzzaman,Echizen, Hidenori,Nishida, Jun-Ichi,Iwata, Takeshi,Tokito, Shizuo,Yamashita, Yoshiro
, p. 841 - 849 (2008/02/04)
A series of phosphorescent cyclometalated iridium(iii) complexes 4-6 with new ligands of bicyclic phenylvinylpyridines have been synthesized and systematically examined for their photophysical, electrochemical and electroluminescence (EL) properties. All
8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS
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Page/Page column 21-22, (2008/06/13)
The present invention is directed to certain 8-phenyl-5,6,7,8-hydroquinolinecompounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceut
CYCLOALKANOPYRIDINE DERIVATIVE
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Page/Page column 32-33, (2010/11/24)
Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.
Electrostatic acceleration of enolization in cationic ketones
Tobin, John B.,Frey, Perry A.
, p. 12253 - 12260 (2007/10/03)
Rate constants for the water, acetate, and hydroxide ion-catalyzed enolizations of the cationic ketones 2-acetyl-1-methylpyridinium ion (3) and 1-methyl-8-oxo-5,6,7,8-tetrahydroquinolinium ion (4) have been measured at 25°C and compared with those reporte
β-Amino Ketones as Key Intermediates in the Synthesis of Pyridines: A Novel and Efficient Route to Annelated Bi- and Terpyridines
Westerwelle, Ulrich,Esser, Achim,Risch, Nikolaus
, p. 571 - 576 (2007/10/02)
The hydrochlorides of β-amino ketones 1a-e (Mannich bases) are easily obtained starting compounds for a novel synthesis of pyridines.Condensation with the heteroaromatic ketones 8, 9, and 10 yields 5,6-dihydro-1,10-phenanthrolines 3a-d, 13 and 4,5-diazafluorenes 4a-d, which have not yet been described in literature.Symmetrical terpyridines 3e, 4e are formed in a one-step reaction of 8, 9 with dimethylmethylenammonium chloride in the presence of an ammonia source.
