287200-82-2

Upstream product

• 287200-81-1 4-(4-but-2-ynyloxyphenylsulfanyl)-4-hydroxycarbamoylpiperidine-1-carboxylic acid tert-butyl ester 
• 1025986-88-2 4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 287201-94-9 4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 287201-93-8 bis(4-but-2-ynyloxyphenyl)disulfide 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 287201-95-0 4-but-2-ynyloxy-benzenethiol 
• 286459-94-7 4-but-2-ynyloxybenzenesulfonyl chloride 

Downstream Products

• 287200-83-3 1-(4-bromo-benzyl)-4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-4-carboxylic acid hydroxyamide 

Relevant academic research and scientific papers

ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS

Compounds of the formula:useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-α converting enzyme and matrix metalloproteinase inhibitors

A series of 4-alkynyloxy phenyl sulfanyl, sulfinyl and sulfony alkyl and piperidine-4-carboxylic acid hydroxamides were synthesized. Their structure-activity relationships, against tumor necrosis factor-α (TACE) and matrix metalloproteinase (MMP) inhibito

Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors

Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.