2873-31-6Relevant academic research and scientific papers
Incorporation of methylated pyrimidine analogues into RNA
Vyle, Joseph S.,Young, Karen J.,Grasby, Jane A.
, p. 5093 - 5096 (2007/10/03)
Routes for the preparation of 2'-silyl protected phosphoramidites of the modified nucleosides O2-methyluridine and O4-methyluridine are described. Methodology for the site-specific incorporation of these phosphonamidetes into a 25 nucleotide long oligoribonucleotide sequence by solid-phase synthesis is reported.
Synthesis of Uridine Analogues to Probe the Functional Group Requirements of the Hairpin Ribozyme
Vyle, Joseph S.,Young, Karen J.,Jones, Sarah,Grasby, Jane A.
, p. S280 - S282 (2007/10/03)
O4-Methyluridine, O2-methyluridine and 4Huridine phosphoramidites were prepared with 2'-O-silyl protection.The methyl modified pyrimidines were synthesised from uridine via the triazolide (O4-methyl) or 2,5'-cyclo derivative (O2-methyl).An improved synthesis of protected 4-thiouridine was also performed.
REACTION OF URACIL NUCLEOSIDES WITH 1-METHYLIMIDAZOLE IN THE PRESENCE OF PHOSPHORYL CHLORIDE: A CONVENIENT METHOD FOR THE SYNTHESIS OF 4-SUBSTITUED PYRIMIDIN-2(1H)-ONE NUCLEOSIDES
Matsuda, Akira,Obi, Kikoh,Miyasaka, Tadashi
, p. 2574 - 2578 (2007/10/02)
Reaction of 2',3',5'-tri-O-benzoyluridine (3) with 1-methylimidazole in the presence of phosphoryl chloride in acetonitrile afforded 3-methyl-1-imidazolium intermediate (4), from which a variety of 4-substituted pyrimidin-2(1H)-one ribosides (5-12) were o
