28734-00-1

Usage

Uses

Used in Oncology:
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE is used as an anti-cancer agent for its potential in inhibiting tumor growth and metastasis in various types of cancer, such as breast and lung cancer. It functions as a potent inhibitor of phosphatidylinositol 4-kinase (PI4K), which plays a crucial role in cancer cell proliferation and survival.
Used in Combination Therapy:
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE is used as a component in combination therapy with other anticancer agents to enhance the overall therapeutic effect and potentially overcome drug resistance in cancer treatment.
Used in Neurology:
4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE is used as a neuroprotective agent for its potential in treating neurodegenerative diseases. Its neuroprotective effects are currently being investigated, offering hope for the development of new treatments for such conditions.

InChI:InChI=1/C16H14N4/c17-16-19-15(14-9-5-2-6-10-14)12-20(16)18-11-13-7-3-1-4-8-13/h1-12H,(H2,17,19)/b18-11+

Upstream product

• 70-11-1 α-bromoacetophenone 
• 3357-37-7 2-benzylidenehydrazinecarboximidamide 
• 100-52-7 benzaldehyde 
• 126-81-8 dimedone 
• 15970-40-8 1,2-diamino-4-phenyl[1H]imidazole 
• 504-02-9 1,3-cylohexanedione 
• 3357-37-7 benzaldehyde diaminomethylenehydrazone 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 132397-45-6 N-(4-Phenyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-imidazol-2-yl)-acetamide 
• 159140-09-7 2-benzylideneamino-4-phenyl-2-triphenylphosphoranylideneamino-1H-imidazole 
• 100-47-0 benzonitrile 
• 159140-07-5 1-amino-4-phenyl-2-triphenylphosphoranylideneamino-1H-imidazole 
• 1222-98-6 4-nitrochalcone 

Relevant academic research and scientific papers

Cascade cyclization of 1,2-diamino-4-phenylimidazole with aromatic aldehydes and cyclohexanediones

The three-component condensation of 1,2-diamino-4-phenylimidazole with aromatic aldehydes and 1,3-cyclohexanediones occurred regioselectively and afforded 3-amino-1-phenyl-10-aryl-7,8-dihydroimidazo[1,5-b] cinnolin-9(5H,6H, 10H)-ones. Pleiades Publishing, Ltd., 2012.

Synthesis of nitrogen-containing heterocycles 10 [1]. Reaction of 2-amino- 1H-imidazole derivatives with ethoxymethylene compounds

The direct annelation reaction of 4-substituted 2-amino-1-benzylideneamino-1H-imidazoles (1) or 2-amino-1-isopropylideneamino-1H-imidazole (8) with ethoxymethylenemalononitrile (I) gave successfully bicyclic imidazo[1,2-a]pyrimidine compounds 2 and 9 in high yields. The reactions of other ethoxymethylene compounds of lower reactivity, i.e., ethyl ethoxymethylenecyanoacetate (II) and diethyl ethoxymethylenemalonate (III), with 2-amino-1H-imidazoles under similar conditions afforded the corresponding enamines 3, 4 and 10, which, upon heating in the presence of an acid or a base, could readily be cyclized to form imidazopyrimidines except for 1-isopropylideneamino compound 10. In general, the 3-phenyl compounds (3b and 4b) did not cyclize to the type 2 compound resulting in a full recovery of the starting enamines.

Synthesis of dihydro derivatives of 2-amino-4,5,7-triarylimidazo[1,5-b]pyridazine

7-Amino-2,4,5-triaryl-3,4-dihydroimidazo[1,5-b]pyridazines have been synthesized by reacting 4-aryl-1,2-diaminoimidazoles with 1,3-diarylpropenones. The structure of one of the products was confirmed by X-ray structural analysis. 1999 Kluwer Academic/Plen

Synthesis of substituted 2-amino-1-arylidenaminoimidazoles and 1-arylidenaminoimidazo[1,2-a]imidazoles

A new method is proposed for the preparation of 2-amino-1-arylidenaminoimidazoles, which react with α-haloketones to give a series of 1-arylidenamino-3-acylmethyl-2-iminoimidazolines and 1-arylidenaminoimidazo[1,2-a]imidazoles depending on the conditions. 1997 Plenum Publishing Corporation.