28734-00-1

Basic information

• Product Name: 4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE
• Synonyms: Imidazole,2-amino-1-(benzylideneamino)-4-phenyl- (8CI); NSC 133598
• CAS NO: 28734-00-1
• Molecular Formula: C₁₆H₁₄N₄
• Molecular Weight: 262.32
• Mol File: 28734-00-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 514.7°Cat760mmHg
• Flash Point: 265.1°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 1.06E-10mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE(28734-00-1)
• EPA Substance Registry System: 4-PHENYL-N~1~-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE(28734-00-1)

Safety Data

• Hazardous Substances Data: 28734-00-1(Hazardous Substances Data)

Usage

General Description

4-PHENYL-N^1^-[(1E)-PHENYLMETHYLENE]-1H-IMIDAZOLE-1,2-DIAMINE, also known as PIK-75, is a chemical compound with molecular formula C21H18N4. It is a potent inhibitor of phosphatidylinositol 4-kinase (PI4K) and has been shown to have anti-cancer properties. PIK-75 has been studied for its potential in inhibiting tumor growth and metastasis in various types of cancer, including breast and lung cancer. It is also being researched for its potential in combination therapy with other anticancer agents. Additionally, PIK-75 has been found to have neuroprotective effects and is being investigated for its potential in treating neurodegenerative diseases. Overall, PIK-75 is a versatile compound with promising therapeutic potential in the fields of oncology and neurology.

InChI:InChI=1/C16H14N4/c17-16-19-15(14-9-5-2-6-10-14)12-20(16)18-11-13-7-3-1-4-8-13/h1-12H,(H2,17,19)/b18-11+

Upstream product

• 3357-37-7 benzaldehyde diaminomethylenehydrazone 
• 532-27-4 1-chloroacetophenone 
• 100-52-7 benzaldehyde 
• 126-81-8 dimedone 
• 15970-40-8 1,2-diamino-4-phenyl[1H]imidazole 
• 504-02-9 1,3-cylohexanedione 
• 70-11-1 α-bromoacetophenone 
• 3357-37-7 2-benzylidenehydrazinecarboximidamide 

Downstream Products

• 159140-09-7 2-benzylideneamino-4-phenyl-2-triphenylphosphoranylideneamino-1H-imidazole 
• 100-47-0 benzonitrile 
• 159140-07-5 1-amino-4-phenyl-2-triphenylphosphoranylideneamino-1H-imidazole 
• 1222-98-6 4-nitrochalcone 
• 132397-45-6 N-(4-Phenyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-imidazol-2-yl)-acetamide 

Relevant articles and documents

Cascade cyclization of 1,2-diamino-4-phenylimidazole with aromatic aldehydes and cyclohexanediones

The three-component condensation of 1,2-diamino-4-phenylimidazole with aromatic aldehydes and 1,3-cyclohexanediones occurred regioselectively and afforded 3-amino-1-phenyl-10-aryl-7,8-dihydroimidazo[1,5-b] cinnolin-9(5H,6H, 10H)-ones. Pleiades Publishing, Ltd., 2012.

Synthesis of dihydro derivatives of 2-amino-4,5,7-triarylimidazo[1,5-b]pyridazine

7-Amino-2,4,5-triaryl-3,4-dihydroimidazo[1,5-b]pyridazines have been synthesized by reacting 4-aryl-1,2-diaminoimidazoles with 1,3-diarylpropenones. The structure of one of the products was confirmed by X-ray structural analysis. 1999 Kluwer Academic/Plen