287389-12-2Relevant articles and documents
Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors
Arnaiz, Damian O.,Zhao, Zuchun,Liang, Amy,Trinh, Lan,Whitlow, Marc,Koovakkat, Sunil K.,Shaw, Kenneth J.
, p. 957 - 961 (2000)
A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a K(i) of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.