287401-29-0Relevant articles and documents
The first syntheses of the 1-oxo-2-oxa-5-azaspiro[3.4]octane ring system found in oxazolomycin
Papillon, Julien P. N.,Taylor, Richard J. K.
, p. 1987 - 1990 (2007/10/03)
matrix presented L-Proline was utilized to prepare an optically active 1-oxo-2-oxa-5-azaspiro[3.4]octane for the first time. The synthesis of the racemic system, using a tandem aldol-lactonization reaction, is also described. Ruthenium tetroxide oxidation of these compounds afforded the corresponding spiro β-lactone γ-lactams.