287404-65-3

Basic information

• Product Name: 1,4-Thiazepine-3-carboxamide, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]hexahydro-N-hydroxy-, (3S)-
• CAS NO: 287404-65-3
• Molecular Formula: C16H20N2O5S2
• Molecular Weight: 384.477
• Mol File: 287404-65-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-Thiazepine-3-carboxamide, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]hexahydro-N-hydroxy-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Thiazepine-3-carboxamide, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]hexahydro-N-hydroxy-, (3S)-(287404-65-3)
• EPA Substance Registry System: 1,4-Thiazepine-3-carboxamide, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]hexahydro-N-hydroxy-, (3S)-(287404-65-3)

Safety Data

• Hazardous Substances Data: 287404-65-3(Hazardous Substances Data)

Upstream product

• 287407-39-0 4-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid tert-butyl ester 
• 1023971-10-9 (-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid 
• 286459-94-7 4-but-2-ynyloxybenzenesulfonyl chloride 

Relevant articles and documents

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors

Potent and selective TACE and MMP inhibitors utilizing the diazepine and thiazepine ring systems were synthesized and evaluated for biological activity in in vitro and in vivo models of TNF-α release. Oral activity in the mouse LPS model of TNF-α release