1023971-10-9

Upstream product

• 921-01-7 D-cysteine 
• 62116-24-9 3-acetoxypropyl iodide 
• 628-09-1 3-Chloropropyl acetate 
• 592-33-6 3-bromopropyl acetate 
• 353-05-9 3-fluoropropyl acetate 
• 52-90-4 L-Cysteine 
• 107-18-6 allyl alcohol 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 287407-38-9 2-(4-but-2-ynyloxy-benzenesulfonylamino)-3-(3-hydroxy-propylsulfanyl)-propionic acid tert-butyl ester 
• 287407-39-0 4-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid tert-butyl ester 
• 287404-65-3 (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid hydroxyamide 
• 287407-40-3 (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid 

Relevant academic research and scientific papers

Preparation method of high-purity fudosteine

The invention discloses a preparation method of high-purity fudosteine, and belongs to the technical field of synthesis of pharmaceutical compounds. The preparation method is characterized in that with 3-halogenated propyl acetate or 3-halogenated propyl propionate and L-cysteine as starting materials, a fudosteine crude product is prepared through a reaction in an aqueous alkali solution, and high-purity fudosteine is obtained by refining the fudosteine crude product. The preparation method has the advantages that the reaction conditions are mild, the reaction process is simple, the yield ishigh, the cost is low, the requirement that the content of unknown impurities is lower than 0.1% can be met, and the preparation method is suitable for industrial application.

Preparation method of fodor stanozolol suitable for industrialized production

The invention relates to a preparation method of fodor stanozolol suitable for industrialized production. According to the preparation method disclosed by the invention, water-ethanol is used as a reaction solvent, amine substances are used as a catalyst, after the reaction is completed, temperature reduction and crystallization are performed, and products are separated in a precipitation form. The whole process is easy to control and high in repeatability, the yield of the fodor stanozolol is stabilized to 95%, and the residue quantity is controlled within 0.05%, so that medical standards are completely met, and the preparation method is very suitable for industrialized production.

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors

Potent and selective TACE and MMP inhibitors utilizing the diazepine and thiazepine ring systems were synthesized and evaluated for biological activity in in vitro and in vivo models of TNF-α release. Oral activity in the mouse LPS model of TNF-α release