287407-12-9

Basic information

• Product Name: [(4-but-2-ynylsulfanyl-benzenesulfonyl)-methyl-amino]-acetic acid
• CAS NO: 287407-12-9
• Molecular Weight: 313.398
• Mol File: 287407-12-9.mol

Chemical Properties

• CAS DataBase Reference: [(4-but-2-ynylsulfanyl-benzenesulfonyl)-methyl-amino]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-but-2-ynylsulfanyl-benzenesulfonyl)-methyl-amino]-acetic acid(287407-12-9)
• EPA Substance Registry System: [(4-but-2-ynylsulfanyl-benzenesulfonyl)-methyl-amino]-acetic acid(287407-12-9)

Safety Data

• Hazardous Substances Data: 287407-12-9(Hazardous Substances Data)

Upstream product

• 287407-11-8 2-[(4-but-2-ynylthiophenylsulfonyl)methylamino]acetic acid tert-butyl ester 
• 287407-07-2 tert-butyl 2-(4-fluoro-N-methylphenylsulfonamido)acetate 
• 13029-71-5 2-(4-fluorophenylsulfonamido)acetic acid 
• 213015-69-1 tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Relevant articles and documents

Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates

The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1′ group, was explored. In particular, compound 5j has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1 and MMP-9, and oral activity in an in vivo model of TNF-α production and a collagen-induced arthritis model.