28748-41-6

Basic information

• Product Name: Benzofuran, 2-(1-methylethyl)-
• Synonyms: Benzofuran, 2-(1-methylethyl)-
• CAS NO: 28748-41-6
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.21
• Mol File: 28748-41-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 216.468°C at 760 mmHg
• Flash Point: 79.62°C
• Appearance: /
• Density: 1.024g/cm³
• Vapor Pressure: 0.205mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzofuran, 2-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 2-(1-methylethyl)-(28748-41-6)
• EPA Substance Registry System: Benzofuran, 2-(1-methylethyl)-(28748-41-6)

Safety Data

• Hazardous Substances Data: 28748-41-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H12O/c1-8(2)11-7-9-5-3-4-6-10(9)12-11/h3-8H,1-2H3

Upstream product

• 271-89-6 1-benzofurane 
• 75-30-9 2-iodo-propane 
• 54008-77-4 2-bromo-1-benzofuran 
• 598-23-2 3-methyl-but-1-yne 
• 533-58-4 2-Iodophenol 
• 695-84-1 2-allylphenol 
• 1273298-53-5 1-isopropylprop-2-en-1-yl 2-vinylphenyl ether 
• 70340-04-4 (2-hydroxybenzyl)triphenylphosphonium bromide 
• 79-30-1 isobutyryl chloride 
• 70340-03-3 bromure d'acetoxy-2 benzyltriphenylphosphonium 
• 95-48-7 ortho-cresol 
• 704-65-4 2-(bromomethyl)phenyl acetate 
• 90-01-7 salicylic alcohol 
• 533-18-6 2-methylphenyl acetate 

Downstream Products

• 91969-36-7 (-)-2-isopropyl-2,3-dihydrobenzofuran 
• 1372790-94-7 (S)-2-isopropyl-2,3-dihydrobenzofuran 
• 74695-08-2 2-isopropyl-2,3-dihydrobenzofuran 

Relevant articles and documents

Copper-catalyzed direct alkylation of heteroarenes

An efficient and broadly applicable process is reported for the direct alkylation of C-H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

Cobalt-Catalyzed Negishi Cross-Coupling Reactions of (Hetero)Arylzinc Reagents with Primary and Secondary Alkyl Bromides and Iodides

We report a cobalt-catalyzed cross-coupling of di(hetero)arylzinc reagents with primary and secondary alkyl iodides or bromides using THF-soluble CoCl2·2 LiCl and TMEDA as a ligand, which leads to the corresponding alkylated products in up to 88% yield. A range of functional groups (e.g. COOR, CN, CF3, F) are tolerated in these substitution reactions. Remarkably, we do not observe rearrangement of secondary alkyl iodides to unbranched products. Additionally, the use of cyclic TBS-protected iodohydrins leads to trans-2-arylcyclohexanol derivatives in excellent diastereoselectivities (up to d.r.=99:1).

Ruthenium NHC catalyzed highly asymmetric hydrogenation of benzofurans

H2-O-T! Aromatic O-heterocycles are a challenging substrates for asymmetric hydrogenation (H2). An in situ formed chiral N-heterocyclic carbene (NHC) ruthenium complex allows the high yielding, completely regioselective, and highly asymmetric hydrogenation of substituted benzofurans at room Temperature, giving valuable 2,3-dihydrobenzofurans (see scheme). Copyright