2875-25-4

Basic information

• Product Name: (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one
• Synonyms: (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one
• CAS NO: 2875-25-4
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.24
• Mol File: 2875-25-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 414.3°Cat760mmHg
• Flash Point: 204.4°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 1.87E-07mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one(2875-25-4)
• EPA Substance Registry System: (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one(2875-25-4)

Safety Data

• Hazardous Substances Data: 2875-25-4(Hazardous Substances Data)

Usage

General Description

The chemical (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is a compound with a molecular formula C15H11NO2. It consists of a pyridine ring and a phenolic group connected to a propenone moiety. (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is commonly used in organic synthesis and medicinal chemistry. It has been reported to exhibit various biological activities, including antibacterial, antifungal, and anti-inflammatory properties. Additionally, it has been studied for its potential use in the treatment of diseases such as cancer and Alzheimer's. Its diverse pharmacological potential makes (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one a valuable compound for further research and development in the field of pharmaceuticals.

InChI:InChI=1/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 3327-27-3 2-(pyridine-3-yl)-4H-chromen-4-one 

Relevant articles and documents

Thallium(III) p-tosylate-mediated oxidative [1,2] rearrangement of 2-naphthyl and 2-heteroarylchromanones

A practical and effective approach towards the synthesis of 3-heteroaryl-4H-chromen-4-ones by the oxidative [1,2] rearrangement of the respective 2-heteroaryl chroman-4-ones using thallium(III) p-tosylate is presented. The oxidative rearrangement of α- an

Ru, Rh and Ir metal complexes of pyridyl chalcone derivatives: Their potent antibacterial activity, comparable cytotoxicity potency and selectivity to cisplatin

Half sandwich ruthenium, rhodium and iridium complexes containing pyridyl chalcone analogues (L1 and L2) are prepared by the reaction of [(arene)M(μ-Cl)Cl]2 (arene = benzene, p-cymene, Cp*) and (M = Ru, Rh/Ir)] with L1 and L2 in 1:2 (M:L) ratio. Eight neutral mononuclear complexes (1–8) were obtained and characterized using FT-IR, 1H NMR, 13C NMR, ESI mass and UV–Vis spectroscopic methods. The molecular structures of complexes 2, 4, 5 and 7 are established by single crystal X-ray diffraction studies. Antibacterial studies were tested against three strains of bacterial microorganisms Staphylococcus aureus (gram +ve), Klebsiella pneumoniae (gram ?ve) and Escherichia coli (gram ?ve). Further the cytotoxicity study of the pyridyl chalcone derivatives and their complexes were evaluated against the human colorectal cancer cell lines HT-29, HCT-116 p53+/+, HCT-116 p53?/? and ARPE-19 (non-cancer retinal epithelium).

Synthesis and selective cytotoxic activities on rhabdomyosarcoma and noncancerous cells of some heterocyclic chalcones

Chemically diverse heterocyclic chalcones were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against rhabdomyosarcoma (RMS) and noncancerous cell line (LLC-PK1). The influence of heteroaryl patte