28754-28-1Relevant academic research and scientific papers
A Light-up Logic Platform for Selective Recognition of Parallel G-Quadruplex Structures via Disaggregation-Induced Emission
Deiana, Marco,Chand, Karam,Jamroskovic, Jan,Obi, Ikenna,Chorell, Erik,Sabouri, Nasim
, p. 896 - 902 (2020)
The design of turn-on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G-quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition-driven disaggregation (on-signal) of an ultrabright coumarin-quinazoline conjugate. The synthesized probe selectively lights-up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label-free molecular logic system. Finally, our molecule preferentially stains the G4-rich nucleoli of cancer cells.
Coumarin and coumarinimide derivatives
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, (2008/06/13)
Disclosed are disperse dyes of formula I, STR1 in which X signifies O or NH, either R1 and R2 each signify an alkyl or phenyl radical, Or R1 is as defined above, and R2 is hydrogen, Or R1 and R2, together with the nitrogen atom, signify a heterocyclic ring R3 signifies acyl, alkyl, phenyl or a heterocyclic, and R4 signifies a chain forming a carbocyclic or heterocyclic ring of aromatic character.
