28754-28-1

Basic information

• Product Name: 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one
• Synonyms: 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one;4(1H)-Quinazolinone, 2-7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl-;2-[7-(Diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-4(1H)-quinazolinone
• CAS NO: 28754-28-1
• Molecular Formula: C₂₁H₁₉N₃O₃
• Molecular Weight: 361.39386
• EINECS: 249-200-1
• Mol File: 28754-28-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 602.6°Cat760mmHg
• Flash Point: 318.2°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 0-0Pa at 20℃
• CAS DataBase Reference: 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one(28754-28-1)
• EPA Substance Registry System: 2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]quinazolin-4(1H)-one(28754-28-1)

Safety Data

• Hazardous Substances Data: 28754-28-1(Hazardous Substances Data)

Usage

Chemical Family

Quinazolinone

Properties

Synthetic organic compound with potential anti-cancer and anti-inflammatory properties

Potential Uses

Studied as a kinase inhibitor for targeted cancer therapies, also demonstrated anti-inflammatory activity for potential treatment of inflammatory conditions

Research

Ongoing research to fully understand biological activity and therapeutic uses

InChI:InChI=1/C21H19N3O3/c1-3-24(4-2)14-10-9-13-11-16(21(26)27-18(13)12-14)19-22-17-8-6-5-7-15(17)20(25)23-19/h5-12H,3-4H2,1-2H3,(H,22,23,25)

Upstream product

• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 118-48-9 isatoic anhydride 

Relevant articles and documents

A Light-up Logic Platform for Selective Recognition of Parallel G-Quadruplex Structures via Disaggregation-Induced Emission

The design of turn-on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G-quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition-driven disaggregation (on-signal) of an ultrabright coumarin-quinazoline conjugate. The synthesized probe selectively lights-up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label-free molecular logic system. Finally, our molecule preferentially stains the G4-rich nucleoli of cancer cells.