287720-99-4

Upstream product

• 109-89-7 diethylamine 
• 59247-47-1 tert-butyl-4-bromobenzoate 
• 289468-31-1 4-[(3-Methoxy-phenyl)-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amino]-benzoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 289468-30-0 (3-Methoxy-phenyl)-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine 
• 532-24-1 tropinone 

Downstream Products

• 289468-26-4 4-[(8-allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-methoxy-phenyl)-amino]-N,N-diethyl-benzamide 
• 364039-20-3 4-[(8-aza-bicyclo[3.2.1]oct-3-yl)-(3-methoxy-phenyl)-amino]-N,N-diethyl-benzamide 

Relevant academic research and scientific papers

Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists

A series of 4-diarylaminotropanes has been prepared. Both endo and exo diastereomeric forms bound to the delta opioid receptor but the endo isomers were more potent and selective versus the μ opioid receptor than the exo isomers. The most potent delta opioid agonist (14) exhibited a delta opioid K(i) of 0.2 nM and was 860-fold selective over mu. (C) 2000 Elsevier Science Ltd. All rights reserved.

4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenz amides: High affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity

The tropane derived compounds, 4-[(8-alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides (5a-d), were synthesized and found to have high affinity and selectivity for the δ receptor. Compounds 5a-d are structurally similar to the full agonist (-)-RTI-5989-54 (3); yet, efficacy studies for compounds in this series (5a-d) reveal greatly diminished agonist activity as well as antagonism not found in piperidine-based compounds like 3. (C) 2000 Elsevier Science Ltd. All rights reserved.