28773-76-4

Upstream product

• 32017-70-2 methyl 2-(4-chlorobenzoyl)benzoate 
• 70775-39-2 dimethylsulfoxonium methylide 
• 1443464-10-5 (Z)-2-[1-(4-chlorophenyl)-2-methoxyethenyl]benzaldehyde 

Downstream Products

• 92608-99-6 C₁₈H₁₅ClO₂S 

Relevant academic research and scientific papers

Synthesis of 4-arylisocoumarins (=4-aryl-1H-2-benzopyran-1-ones) through acidic hydrolysis of (Z)-2-(1-aryl-2-methoxyethenyl)benzaldehydes, followed by oxidation

4-Arylisocoumarins (=4-aryl-1H-2-benzopyran-1-ones) 6 were prepared from 2-(1-aryl-2-methoxyethenyl)-1-bromobenzenes 1. Successive treatment of these bromo styrenes with BuLi and 1-formylpiperidine gave a mixture of (E)- and (Z)-2-(1-aryl-2-methoxyethenyl)benzaldehydes 2. Hydrolysis of (Z)-isomers with conc. HBr, followed by pyridinium chlorochromate (PCC) oxidation of the resulting 1H-2-benzopyran-1-ol derivatives 4 (and 5), afforded the desired products. Copyright

REACTIONS OF 2-ACYLBENZOATES WITH DIMETHYLOXOSULPHONIUM METHYLIDE: A NOVEL ROUTE TO ISOCOUMARINS

Treatment of 2-benzoylbenzoates with dimethyloxosulphonium methylide (1) gives 4-phenylisocoumarins (2); methyl 2-acetylbenzoate gives 4-methylene-3,4-dihydroisocoumarin (3) under the same conditions.