32017-70-2

Basic information

• Product Name: Benzoic acid, 2-(4-chlorobenzoyl)-, methyl ester
• CAS NO: 32017-70-2
• Molecular Formula: C15H11ClO3
• Molecular Weight: 274.704
• Mol File: 32017-70-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(4-chlorobenzoyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(4-chlorobenzoyl)-, methyl ester(32017-70-2)
• EPA Substance Registry System: Benzoic acid, 2-(4-chlorobenzoyl)-, methyl ester(32017-70-2)

Safety Data

• Hazardous Substances Data: 32017-70-2(Hazardous Substances Data)

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 1679-18-1 4-Chlorophenylboronic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 67-56-1 methanol 
• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 92608-99-6 C₁₈H₁₅ClO₂S 
• 28773-76-4 4-(4-chlorophenyl)-1H-2-benzopyran-1-one 
• 131-09-9 2-chloroanthracene-9,10-dione 
• 51476-10-9 ethyl 2-(4-chlorobenzoyl)benzoate 

Relevant articles and documents

Construction of an isoquinolinone framework from carboxylic-ester-directed umpolung ring opening of methylenecyclopropanes

An interesting type of reaction involving functionalized methylenecyclopropanes (MCPs) has been revealed. Here, a nucleophilic attack of an anionic species onto a partially polarity-reversed MCP was realized by treating a neighbouring carboxylic ester tethered to the MCP and amine with KHMDS to realize an umpolung ring opening of the MCP. This work established an operationally convenient protocol for the rapid construction of isoquinolinone frameworks. This journal is

Expedient carbonylation of aryl halides in aqueous or neat condition

An expedient and versatile, microwave-assisted procedure for the carbonylation of aryl halides with boronic acids, alcohols or amines in water or under neat conditions has been developed. The reaction is catalyzed by fluorous, oxime-based palladacycle 1 that shows an excellent recyclable property and low levels of Pd leaching. To demonstrate the usefulness of the protocol, we applied it to the preparation of compounds of pharmaceutical interest, including a precursor of the reverse transcriptase inhibitor, niacin, benzocaine and butamben.

Preparation of polyfunctional arylmagnesium, arylzinc, and benzylic zinc reagents by using magnesium in the presence of LiCl

The presence of LiCl considerably facilitates the insertion of magnesium into various aromatic and heterocyclic bromides. Several functional groups, such as -OBoc, -OTs, -Cl, -F, -CF3, -OMe, -NMe2, and -N 2NR2, are well tolerated. The presence of a cyano group leads in some cases to competitive reduction of the organic halide to the corresponding ArH compound. The presence of sensitive groups such as methyl or ethyl ester is tolerated upon in situ trapping of the intermediate magnesium reagent with ZnCl2. This method can also be applied to the preparation of functionalized benzylic zinc reagents from benzylic chlorides. In the case of di- or tribromoaryl derivatives, directing groups such as -OPiv, -OTs, -N2NR2, or -OAc orient the zinc insertion (Zn/LiCl) to the ortho-position, while the reaction with Mg/LiCl or Mg/LiCl/ZnCl 2 leads to regioselective insertion into the para-carbon-bromine bond. Large-scale experiments (20-100 mmol) for all of the metalation procedures are described.