287737-60-4Relevant academic research and scientific papers
Conformationally constrained 2′-N,4′-C-ethylene-bridged thymidine (Aza-ENA-T): Synthesis, structure, physical, and biochemical studies of Aza-ENA-T-modified oligonucleotides
Varghese, Oommen P.,Barman, Jharna,Pathmasiri, Wimal,Plashkevych, Oleksandr,Honcharenko, Dmytro,Chattopadhyaya, Jyoti
, p. 15173 - 15187 (2007/10/03)
The 2′-deoxy-2′-N,4′-C-ethylene-bridged thymidine (aza-ENA-T) has been synthesized using a key cyclization step involving 2′-ara-trifluoromethylsufonyl-4′-cyanomethylene 11 to give a pair of 3′,5′-bis-OBn-protected diastereomerically pure aza-ENA-Ts (12a
